| pubmed-article:12642660 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12642660 | lifeskim:mentions | umls-concept:C0004611 | lld:lifeskim |
| pubmed-article:12642660 | lifeskim:mentions | umls-concept:C0815047 | lld:lifeskim |
| pubmed-article:12642660 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:12642660 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:12642660 | pubmed:dateCreated | 2003-4-2 | lld:pubmed |
| pubmed-article:12642660 | pubmed:abstractText | Transcriptional activator proteins in bacteria often operate by interaction with the C-terminal domain of the alpha-subunit of RNA polymerase (RNAP). Here we report the discovery of an "anti-alpha" factor Spx in Bacillus subtilis that blocks transcriptional activation by binding to the alpha-C-terminal domain, thereby interfering with the capacity of RNAP to respond to certain activator proteins. Spx disrupts complex formation between the activator proteins ResD and ComA and promoter-bound RNAP, and it does so by direct interaction with the alpha-subunit. ResD- and ComA-stimulated transcription requires the proteolytic elimination of Spx by the ATP-dependent protease ClpXP. Spx represents a class of transcriptional regulators that inhibit activator-stimulated transcription by interaction with alpha. | lld:pubmed |
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| pubmed-article:12642660 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12642660 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12642660 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12642660 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12642660 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:12642660 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:12642660 | pubmed:author | pubmed-author:NakanoShunjiS | lld:pubmed |
| pubmed-article:12642660 | pubmed:author | pubmed-author:ZhangYingY | lld:pubmed |
| pubmed-article:12642660 | pubmed:author | pubmed-author:NakanoMichiko... | lld:pubmed |
| pubmed-article:12642660 | pubmed:author | pubmed-author:ZuberPeterP | lld:pubmed |
| pubmed-article:12642660 | pubmed:author | pubmed-author:Leelakriangsa... | lld:pubmed |
| pubmed-article:12642660 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12642660 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:12642660 | pubmed:volume | 100 | lld:pubmed |
| pubmed-article:12642660 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12642660 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12642660 | pubmed:pagination | 4233-8 | lld:pubmed |
| pubmed-article:12642660 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:12642660 | pubmed:meshHeading | pubmed-meshheading:12642660... | lld:pubmed |
| pubmed-article:12642660 | pubmed:meshHeading | pubmed-meshheading:12642660... | lld:pubmed |
| pubmed-article:12642660 | pubmed:meshHeading | pubmed-meshheading:12642660... | lld:pubmed |
| pubmed-article:12642660 | pubmed:meshHeading | pubmed-meshheading:12642660... | lld:pubmed |
| pubmed-article:12642660 | pubmed:meshHeading | pubmed-meshheading:12642660... | lld:pubmed |
| pubmed-article:12642660 | pubmed:meshHeading | pubmed-meshheading:12642660... | lld:pubmed |
| pubmed-article:12642660 | pubmed:meshHeading | pubmed-meshheading:12642660... | lld:pubmed |
| pubmed-article:12642660 | pubmed:meshHeading | pubmed-meshheading:12642660... | lld:pubmed |
| pubmed-article:12642660 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12642660 | pubmed:articleTitle | A regulatory protein that interferes with activator-stimulated transcription in bacteria. | lld:pubmed |
| pubmed-article:12642660 | pubmed:affiliation | Department of Environmental and Biomolecular Systems, OGI School of Science and Engineering, Oregon Health and Science University, Beaverton, OR 97006, USA. | lld:pubmed |
| pubmed-article:12642660 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12642660 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12642660 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:12642660 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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