| pubmed-article:12642396 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12642396 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:12642396 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:12642396 | lifeskim:mentions | umls-concept:C0058193 | lld:lifeskim |
| pubmed-article:12642396 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:12642396 | pubmed:dateCreated | 2003-3-18 | lld:pubmed |
| pubmed-article:12642396 | pubmed:abstractText | (1) Dimemorfan, an antitussive for more than 25 years, has previously been reported to be a relative high-affinity ligand at sigma-1 (sigma(1)) receptor with the K(i) value of 151 nM. (2) To test whether dimemorfan has anti-amnesic effects similar to a sigma(1) receptor agonist, this study examined its effects on scopolamine- and beta-amyloid peptide-(25-35)-induced amnesia in mice. (3) Dimemorfan (10-40 mg kg(-1), i.p.) administered 30 min before the training trial, immediately after the training trial, or 30 min before the retention test significantly improved scopolamine (1 mg kg(-1), i.p.)- or beta-amyloid peptide-(25-35) (3 nmol mouse(-1), i.c.v.)-induced amnesia in a step-through passive avoidance test. Dimemorfan (5-40 mg kg(-1), i.p.) pretreatment also attenuated scopolamine (8 mg kg(-1), i.p.)-induced amnesia in a water-maze test. And, these anti-amnesic effects of dimemorfan, like the putative sigma(1) receptor agonist (+)-N-allylnormetazocine ((+)-SKF-10047), were antagonized by a sigma receptor antagonist haloperidol (0.25 mg kg(-1), i.p.). (4) These results indicated that dimemorfan has anti-amnesic effects and acts like a sigma(1) receptor agonist. | lld:pubmed |
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| pubmed-article:12642396 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12642396 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12642396 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12642396 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:12642396 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:12642396 | pubmed:author | pubmed-author:ChenChieh-FuC... | lld:pubmed |
| pubmed-article:12642396 | pubmed:author | pubmed-author:LiaoJyh-FeiJF | lld:pubmed |
| pubmed-article:12642396 | pubmed:author | pubmed-author:WangHui-HungH... | lld:pubmed |
| pubmed-article:12642396 | pubmed:author | pubmed-author:ChienJyh-WeiJ... | lld:pubmed |
| pubmed-article:12642396 | pubmed:author | pubmed-author:ChouYueh-Chin... | lld:pubmed |
| pubmed-article:12642396 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12642396 | pubmed:volume | 138 | lld:pubmed |
| pubmed-article:12642396 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12642396 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12642396 | pubmed:pagination | 941-9 | lld:pubmed |
| pubmed-article:12642396 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:12642396 | pubmed:meshHeading | pubmed-meshheading:12642396... | lld:pubmed |
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| pubmed-article:12642396 | pubmed:meshHeading | pubmed-meshheading:12642396... | lld:pubmed |
| pubmed-article:12642396 | pubmed:meshHeading | pubmed-meshheading:12642396... | lld:pubmed |
| pubmed-article:12642396 | pubmed:meshHeading | pubmed-meshheading:12642396... | lld:pubmed |
| pubmed-article:12642396 | pubmed:meshHeading | pubmed-meshheading:12642396... | lld:pubmed |
| pubmed-article:12642396 | pubmed:meshHeading | pubmed-meshheading:12642396... | lld:pubmed |
| pubmed-article:12642396 | pubmed:meshHeading | pubmed-meshheading:12642396... | lld:pubmed |
| pubmed-article:12642396 | pubmed:meshHeading | pubmed-meshheading:12642396... | lld:pubmed |
| pubmed-article:12642396 | pubmed:meshHeading | pubmed-meshheading:12642396... | lld:pubmed |
| pubmed-article:12642396 | pubmed:meshHeading | pubmed-meshheading:12642396... | lld:pubmed |
| pubmed-article:12642396 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12642396 | pubmed:articleTitle | Anti-amnesic effect of dimemorfan in mice. | lld:pubmed |
| pubmed-article:12642396 | pubmed:affiliation | Department & Institute of Pharmacology, National Yang-Ming University, No. 155, Sec. 2, Li-Nong Street, Taipei 112, Taiwan. | lld:pubmed |
