| pubmed-article:12566313 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12566313 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:12566313 | lifeskim:mentions | umls-concept:C1707929 | lld:lifeskim |
| pubmed-article:12566313 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:12566313 | lifeskim:mentions | umls-concept:C0011155 | lld:lifeskim |
| pubmed-article:12566313 | lifeskim:mentions | umls-concept:C1523544 | lld:lifeskim |
| pubmed-article:12566313 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:12566313 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12566313 | pubmed:dateCreated | 2003-2-4 | lld:pubmed |
| pubmed-article:12566313 | pubmed:abstractText | PTEN is a tumor suppressor gene mutated in many human cancers. We used the Cre-loxP system to generate a keratinocyte-specific null mutation of Pten in mice (k5Pten(flox/flox) mice). k5Pten(flox/flox) mice exhibit wrinkled skin because of epidermal hyperplasia and hyperkeratosis and ruffled, shaggy, and curly hair. Histological examination revealed that skin morphogenesis is accelerated in k5Pten(flox/flox) mice. Within 3 weeks of birth, 90% of k5Pten(flox/flox) mice die of malnutrition possibly caused by hyperkeratosis of the esophagus. All k5Pten(flox/flox) mice develop spontaneous tumors within 8.5 months of birth, and chemical treatment accelerates the onset of tumors. k5Pten(flox/flox) keratinocytes are hyperproliferative and resistant to apoptosis and show increased activation of the Pten downstream signaling mediators Akt/protein kinase B (PKB) and extracellular signal-regulated kinase. Pten is thus an important regulator of normal development and oncogenesis in the skin. | lld:pubmed |
| pubmed-article:12566313 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12566313 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12566313 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12566313 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12566313 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12566313 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:12566313 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:12566313 | pubmed:author | pubmed-author:ManabeMotomuM | lld:pubmed |
| pubmed-article:12566313 | pubmed:author | pubmed-author:TakedaJunjiJ | lld:pubmed |
| pubmed-article:12566313 | pubmed:author | pubmed-author:ItamiSatoshiS | lld:pubmed |
| pubmed-article:12566313 | pubmed:author | pubmed-author:HamadaKoichiK | lld:pubmed |
| pubmed-article:12566313 | pubmed:author | pubmed-author:SuzukiAkiraA | lld:pubmed |
| pubmed-article:12566313 | pubmed:author | pubmed-author:SenooHarukiH | lld:pubmed |
| pubmed-article:12566313 | pubmed:author | pubmed-author:SasakiTakehik... | lld:pubmed |
| pubmed-article:12566313 | pubmed:author | pubmed-author:NakanoToruT | lld:pubmed |
| pubmed-article:12566313 | pubmed:author | pubmed-author:InoueTaeT | lld:pubmed |
| pubmed-article:12566313 | pubmed:author | pubmed-author:OhishiMinakoM | lld:pubmed |
| pubmed-article:12566313 | pubmed:author | pubmed-author:KomazawaNobuy... | lld:pubmed |
| pubmed-article:12566313 | pubmed:author | pubmed-author:MakTak WahTW | lld:pubmed |
| pubmed-article:12566313 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12566313 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:12566313 | pubmed:volume | 63 | lld:pubmed |
| pubmed-article:12566313 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12566313 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12566313 | pubmed:pagination | 674-81 | lld:pubmed |
| pubmed-article:12566313 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:12566313 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12566313 | pubmed:articleTitle | Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation. | lld:pubmed |
| pubmed-article:12566313 | pubmed:affiliation | Department of Biochemistry, Akita University School of Medicine, Akita 010-8543, Japan. | lld:pubmed |
| pubmed-article:12566313 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12566313 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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