| pubmed-article:12565949 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12565949 | lifeskim:mentions | umls-concept:C0014898 | lld:lifeskim |
| pubmed-article:12565949 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:12565949 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:12565949 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:12565949 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:12565949 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:12565949 | lifeskim:mentions | umls-concept:C0057173 | lld:lifeskim |
| pubmed-article:12565949 | lifeskim:mentions | umls-concept:C0243072 | lld:lifeskim |
| pubmed-article:12565949 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12565949 | pubmed:dateCreated | 2003-2-4 | lld:pubmed |
| pubmed-article:12565949 | pubmed:abstractText | A novel series of C-8 ester derivatives of leinamycin are described. Condensation of N-substituted amino acids or carboxylic acids containing polyether moiety with leinamycin resulted in the C-8 ester derivatives with good antitumor activity in several experimental models. Among these derivatives, compound 4e, which has five ethylene glycol ether units in the C-8 acyl group, showed potent antitumor activity against human tumor xenograft. Combination with the modification of the dithiolanone moiety was applied to these C-8 ester derivatives and some of them also showed good antitumor activity. | lld:pubmed |
| pubmed-article:12565949 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12565949 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12565949 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12565949 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12565949 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12565949 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12565949 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12565949 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12565949 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12565949 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12565949 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12565949 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:12565949 | pubmed:issn | 0960-894X | lld:pubmed |
| pubmed-article:12565949 | pubmed:author | pubmed-author:KawashimaKenj... | lld:pubmed |
| pubmed-article:12565949 | pubmed:author | pubmed-author:TamaokiTatsuy... | lld:pubmed |
| pubmed-article:12565949 | pubmed:author | pubmed-author:KandaYutakaY | lld:pubmed |
| pubmed-article:12565949 | pubmed:author | pubmed-author:AshizawaTadas... | lld:pubmed |
| pubmed-article:12565949 | pubmed:author | pubmed-author:IkedaShun-ich... | lld:pubmed |
| pubmed-article:12565949 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12565949 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:12565949 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:12565949 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12565949 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12565949 | pubmed:pagination | 455-8 | lld:pubmed |
| pubmed-article:12565949 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:12565949 | pubmed:meshHeading | pubmed-meshheading:12565949... | lld:pubmed |
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| pubmed-article:12565949 | pubmed:meshHeading | pubmed-meshheading:12565949... | lld:pubmed |
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| pubmed-article:12565949 | pubmed:meshHeading | pubmed-meshheading:12565949... | lld:pubmed |
| pubmed-article:12565949 | pubmed:meshHeading | pubmed-meshheading:12565949... | lld:pubmed |
| pubmed-article:12565949 | pubmed:meshHeading | pubmed-meshheading:12565949... | lld:pubmed |
| pubmed-article:12565949 | pubmed:meshHeading | pubmed-meshheading:12565949... | lld:pubmed |
| pubmed-article:12565949 | pubmed:meshHeading | pubmed-meshheading:12565949... | lld:pubmed |
| pubmed-article:12565949 | pubmed:meshHeading | pubmed-meshheading:12565949... | lld:pubmed |
| pubmed-article:12565949 | pubmed:meshHeading | pubmed-meshheading:12565949... | lld:pubmed |
| pubmed-article:12565949 | pubmed:meshHeading | pubmed-meshheading:12565949... | lld:pubmed |
| pubmed-article:12565949 | pubmed:meshHeading | pubmed-meshheading:12565949... | lld:pubmed |
| pubmed-article:12565949 | pubmed:meshHeading | pubmed-meshheading:12565949... | lld:pubmed |
| pubmed-article:12565949 | pubmed:meshHeading | pubmed-meshheading:12565949... | lld:pubmed |
| pubmed-article:12565949 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12565949 | pubmed:articleTitle | Synthesis and antitumor activity of novel C-8 ester derivatives of leinamycin. | lld:pubmed |
| pubmed-article:12565949 | pubmed:affiliation | Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd., 1188 Shimotogari, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8731, Japan. ykanda@kyowa.co.jp | lld:pubmed |
| pubmed-article:12565949 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:12565949 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12565949 | lld:pubmed |
