| pubmed-article:12543077 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12543077 | lifeskim:mentions | umls-concept:C0021756 | lld:lifeskim |
| pubmed-article:12543077 | lifeskim:mentions | umls-concept:C1335875 | lld:lifeskim |
| pubmed-article:12543077 | lifeskim:mentions | umls-concept:C1367307 | lld:lifeskim |
| pubmed-article:12543077 | lifeskim:mentions | umls-concept:C1705050 | lld:lifeskim |
| pubmed-article:12543077 | lifeskim:mentions | umls-concept:C0079773 | lld:lifeskim |
| pubmed-article:12543077 | lifeskim:mentions | umls-concept:C1335280 | lld:lifeskim |
| pubmed-article:12543077 | lifeskim:mentions | umls-concept:C1519726 | lld:lifeskim |
| pubmed-article:12543077 | lifeskim:mentions | umls-concept:C1155551 | lld:lifeskim |
| pubmed-article:12543077 | lifeskim:mentions | umls-concept:C0883208 | lld:lifeskim |
| pubmed-article:12543077 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:12543077 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:12543077 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:12543077 | pubmed:dateCreated | 2003-1-24 | lld:pubmed |
| pubmed-article:12543077 | pubmed:abstractText | The phosphotyrosine phosphatase SHP2 has been suggested to regulate activation of MAPK, Stat3, and Stat5 in several experimental models. In this study we investigated the role of SHP2 in IL-2 induced activation of MAPK and the Stat proteins using the human CTCL cell line MyLa2059 derived from a cutaneous T cell lymphoma (CTCL). For this purpose, MyLa2059 cells were stably transfected with wild-type SHP2 or inactive SHP2. The cells transfected with inactive SHP2 showed reduced MAPK activation upon IL-2 stimulation, suggesting that SHP2 upregulates IL-2 induced MAPK activation in T cells. However, the constitutive tyrosine phosphorylation of Stat3 as well as IL-2 induced Stat5 tyrosine phosphorylation and DNA binding were unaffected by the stably transfected wild-type SHP2 as well as the inactive SHP2. In conclusion, we show for the first time that SHP2 positively regulates IL-2 induced MAPK activation in malignant T cells. Furthermore, the results indicate that SHP2 may not be involved in the activation of Stat3 or Stat5 in CTCL cells. | lld:pubmed |
| pubmed-article:12543077 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12543077 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12543077 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12543077 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12543077 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12543077 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12543077 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12543077 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12543077 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12543077 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12543077 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12543077 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12543077 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12543077 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12543077 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12543077 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12543077 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12543077 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12543077 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12543077 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12543077 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12543077 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12543077 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12543077 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12543077 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12543077 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:12543077 | pubmed:issn | 1043-4666 | lld:pubmed |
| pubmed-article:12543077 | pubmed:author | pubmed-author:MustelinTomas... | lld:pubmed |
| pubmed-article:12543077 | pubmed:author | pubmed-author:ZhangQianQ | lld:pubmed |
| pubmed-article:12543077 | pubmed:author | pubmed-author:WasikMariusz... | lld:pubmed |
| pubmed-article:12543077 | pubmed:author | pubmed-author:RöpkeCarstenC | lld:pubmed |
| pubmed-article:12543077 | pubmed:author | pubmed-author:KaltoftKeldK | lld:pubmed |
| pubmed-article:12543077 | pubmed:author | pubmed-author:ØdumNielsN | lld:pubmed |
| pubmed-article:12543077 | pubmed:author | pubmed-author:WoetmannAnder... | lld:pubmed |
| pubmed-article:12543077 | pubmed:author | pubmed-author:Lundin... | lld:pubmed |
| pubmed-article:12543077 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12543077 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:12543077 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:12543077 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12543077 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12543077 | pubmed:pagination | 141-7 | lld:pubmed |
| pubmed-article:12543077 | pubmed:dateRevised | 2011-11-2 | lld:pubmed |
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| pubmed-article:12543077 | pubmed:meshHeading | pubmed-meshheading:12543077... | lld:pubmed |
| pubmed-article:12543077 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12543077 | pubmed:articleTitle | SHP2 regulates IL-2 induced MAPK activation, but not Stat3 or Stat5 tyrosine phosphorylation, in cutaneous T cell lymphoma cells. | lld:pubmed |
| pubmed-article:12543077 | pubmed:affiliation | Institute of Medical Microbiology and Immunology, University of Copenhagen, Blegdamsvej 3c, 2200 Copenhagen-N, Denmark. | lld:pubmed |
| pubmed-article:12543077 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12543077 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12543077 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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