| pubmed-article:12533482 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12533482 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:12533482 | lifeskim:mentions | umls-concept:C0528412 | lld:lifeskim |
| pubmed-article:12533482 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12533482 | pubmed:dateCreated | 2003-1-20 | lld:pubmed |
| pubmed-article:12533482 | pubmed:abstractText | A partial screen for genetic elements integrated into completely sequenced bacterial genomes shows more significant bias in specificity for the tmRNA gene (ssrA) than for any type of tRNA gene. Horizontal gene transfer, a major avenue of bacterial evolution, was assessed by focusing on elements using this single attachment locus. Diverse elements use ssrA; among enterobacteria alone, at least four different integrase subfamilies have independently evolved specificity for ssrA, and almost every strain analyzed presents a unique set of integrated elements. Even elements using essentially the same integrase can be very diverse, as is a group with an ssrA-specific integrase of the P4 subfamily. This same integrase appears to promote damage routinely at attachment sites, which may be adaptive. Elements in arrays can recombine; one such event mediated by invertible DNA segments within neighboring elements likely explains the monophasic nature of Salmonella enterica serovar Typhi. One of a limited set of conserved sequences occurs at the attachment site of each enterobacterial element, apparently serving as a transcriptional terminator for ssrA. Elements were usually found integrated into tRNA-like sequence at the 3' end of ssrA, at subsites corresponding to those used in tRNA genes; an exception was found at the non-tRNA-like 3' end produced by ssrA gene permutation in cyanobacteria, suggesting that, during the evolution of new site specificity by integrases, tropism toward a conserved 3' end of an RNA gene may be as strong as toward a tRNA-like sequence. The proximity of ssrA and smpB, which act in concert, was also surveyed. | lld:pubmed |
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| pubmed-article:12533482 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12533482 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12533482 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12533482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12533482 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12533482 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:12533482 | pubmed:issn | 0021-9193 | lld:pubmed |
| pubmed-article:12533482 | pubmed:author | pubmed-author:WilliamsKelly... | lld:pubmed |
| pubmed-article:12533482 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12533482 | pubmed:volume | 185 | lld:pubmed |
| pubmed-article:12533482 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12533482 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12533482 | pubmed:pagination | 1059-70 | lld:pubmed |
| pubmed-article:12533482 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:12533482 | pubmed:meshHeading | pubmed-meshheading:12533482... | lld:pubmed |
| pubmed-article:12533482 | pubmed:meshHeading | pubmed-meshheading:12533482... | lld:pubmed |
| pubmed-article:12533482 | pubmed:meshHeading | pubmed-meshheading:12533482... | lld:pubmed |
| pubmed-article:12533482 | pubmed:meshHeading | pubmed-meshheading:12533482... | lld:pubmed |
| pubmed-article:12533482 | pubmed:meshHeading | pubmed-meshheading:12533482... | lld:pubmed |
| pubmed-article:12533482 | pubmed:meshHeading | pubmed-meshheading:12533482... | lld:pubmed |
| pubmed-article:12533482 | pubmed:meshHeading | pubmed-meshheading:12533482... | lld:pubmed |
| pubmed-article:12533482 | pubmed:meshHeading | pubmed-meshheading:12533482... | lld:pubmed |
| pubmed-article:12533482 | pubmed:meshHeading | pubmed-meshheading:12533482... | lld:pubmed |
| pubmed-article:12533482 | pubmed:meshHeading | pubmed-meshheading:12533482... | lld:pubmed |
| pubmed-article:12533482 | pubmed:meshHeading | pubmed-meshheading:12533482... | lld:pubmed |
| pubmed-article:12533482 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12533482 | pubmed:articleTitle | Traffic at the tmRNA gene. | lld:pubmed |
| pubmed-article:12533482 | pubmed:affiliation | Department of Biology, Indiana University, 1001 E. Third Street, Bloomington, IN 47405, USA. kellwill@indiana.edu | lld:pubmed |
| pubmed-article:12533482 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12533482 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
