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pubmed-article:12515583pubmed:abstractTextIt has been suggested that rates of protein evolution are influenced, to a great extent, by the proportion of amino acid residues that are directly involved in protein function. In agreement with this hypothesis, recent work has shown a negative correlation between evolutionary rates and the number of protein-protein interactions. However, the extent to which the number of protein-protein interactions influences evolutionary rates remains unclear. Here, we address this question at several different levels of evolutionary relatedness.lld:pubmed
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pubmed-article:12515583pubmed:articleTitleNo simple dependence between protein evolution rate and the number of protein-protein interactions: only the most prolific interactors tend to evolve slowly.lld:pubmed
pubmed-article:12515583pubmed:affiliationNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA. jordan@ncbi.nlm.nih.govlld:pubmed
pubmed-article:12515583pubmed:publicationTypeJournal Articlelld:pubmed
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