| pubmed-article:12436486 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12436486 | lifeskim:mentions | umls-concept:C0019381 | lld:lifeskim |
| pubmed-article:12436486 | lifeskim:mentions | umls-concept:C0026769 | lld:lifeskim |
| pubmed-article:12436486 | lifeskim:mentions | umls-concept:C0012634 | lld:lifeskim |
| pubmed-article:12436486 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:12436486 | lifeskim:mentions | umls-concept:C1707520 | lld:lifeskim |
| pubmed-article:12436486 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12436486 | pubmed:dateCreated | 2002-11-18 | lld:pubmed |
| pubmed-article:12436486 | pubmed:abstractText | This study examined the association between HHV-6 infection and multiple sclerosis (MS) and the relationship between HHV-6 reactivation and disease activity. The frequency of HHV-6 genomic sequences in peripheral blood mononuclear cells (PBMCs), the incidence of plasma viremia (nPCR), the transcription of viral mRNA in PBMCs (RT-PCR), the presence of antiviral IgM and IgG class antibodies in the plasma (IFA) of 16 relapsing/remitting and secondary progressive MS patients were studied in comparison with clinical manifestations of the disease, magnetic resonance imaging (MRI) of brain, and serum interleukin (IL)-12 concentrations (ELISA). The prevalence of HHV-6 infection was significantly higher in patients with MS (16/26) than in patients with other neurological diseases (6/21) and in blood donors (43/150). HHV-6 reactivation was found during periods of disease activity with Gadolinium-enhancing lesions on MRI in both relapsing/remitting and secondary progressive MS (10/13; 76.9%). In patients with active MS disease, serum concentrations of IL-12 were significantly higher in those patients with active HHV-6 infection than in patients with latent infection. The data confirm an association between HHV-6 infection and MS and show a correlation between HHV-6 reactivation and disease activity in relapsing/remitting and secondary progressive MS. The risk of an exacerbation of MS was significantly higher (P < 0.005) in patients with active HHV-6 infection than in patients with latent infection. A clear correlation between HHV-6 reactivation and serum IL-12 concentrations during disease activity has been demonstrated. The results suggest that HHV-6 reactivation is implicated in exacerbation of MS, possibly through modulation of IL-12 synthesis. | lld:pubmed |
| pubmed-article:12436486 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12436486 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12436486 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12436486 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12436486 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12436486 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12436486 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:12436486 | pubmed:issn | 0146-6615 | lld:pubmed |
| pubmed-article:12436486 | pubmed:author | pubmed-author:ChapenkoSvetl... | lld:pubmed |
| pubmed-article:12436486 | pubmed:author | pubmed-author:MillersAndrej... | lld:pubmed |
| pubmed-article:12436486 | pubmed:author | pubmed-author:NoraZaigaZ | lld:pubmed |
| pubmed-article:12436486 | pubmed:author | pubmed-author:LoginaInaraI | lld:pubmed |
| pubmed-article:12436486 | pubmed:author | pubmed-author:KukaineRitaR | lld:pubmed |
| pubmed-article:12436486 | pubmed:author | pubmed-author:MurovskaModra... | lld:pubmed |
| pubmed-article:12436486 | pubmed:copyrightInfo | Copyright 2003 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:12436486 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12436486 | pubmed:volume | 69 | lld:pubmed |
| pubmed-article:12436486 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12436486 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12436486 | pubmed:pagination | 111-7 | lld:pubmed |
| pubmed-article:12436486 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12436486 | pubmed:meshHeading | pubmed-meshheading:12436486... | lld:pubmed |
| pubmed-article:12436486 | pubmed:meshHeading | pubmed-meshheading:12436486... | lld:pubmed |
| pubmed-article:12436486 | pubmed:meshHeading | pubmed-meshheading:12436486... | lld:pubmed |
| pubmed-article:12436486 | pubmed:meshHeading | pubmed-meshheading:12436486... | lld:pubmed |
| pubmed-article:12436486 | pubmed:meshHeading | pubmed-meshheading:12436486... | lld:pubmed |
| pubmed-article:12436486 | pubmed:meshHeading | pubmed-meshheading:12436486... | lld:pubmed |
| pubmed-article:12436486 | pubmed:meshHeading | pubmed-meshheading:12436486... | lld:pubmed |
| pubmed-article:12436486 | pubmed:meshHeading | pubmed-meshheading:12436486... | lld:pubmed |
| pubmed-article:12436486 | pubmed:meshHeading | pubmed-meshheading:12436486... | lld:pubmed |
| pubmed-article:12436486 | pubmed:meshHeading | pubmed-meshheading:12436486... | lld:pubmed |
| pubmed-article:12436486 | pubmed:meshHeading | pubmed-meshheading:12436486... | lld:pubmed |
| pubmed-article:12436486 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12436486 | pubmed:articleTitle | Correlation between HHV-6 reactivation and multiple sclerosis disease activity. | lld:pubmed |
| pubmed-article:12436486 | pubmed:affiliation | August Kirchenstein Institute of Microbiology and Virology, University of Latvia, Riga, Latvia. modra@latnet.lv | lld:pubmed |
| pubmed-article:12436486 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12436486 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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