| pubmed-article:12423307 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12423307 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:12423307 | lifeskim:mentions | umls-concept:C0021758 | lld:lifeskim |
| pubmed-article:12423307 | lifeskim:mentions | umls-concept:C0021759 | lld:lifeskim |
| pubmed-article:12423307 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:12423307 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:12423307 | lifeskim:mentions | umls-concept:C0085862 | lld:lifeskim |
| pubmed-article:12423307 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:12423307 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:12423307 | lifeskim:mentions | umls-concept:C1299583 | lld:lifeskim |
| pubmed-article:12423307 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:12423307 | lifeskim:mentions | umls-concept:C1608386 | lld:lifeskim |
| pubmed-article:12423307 | lifeskim:mentions | umls-concept:C1549571 | lld:lifeskim |
| pubmed-article:12423307 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:12423307 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12423307 | pubmed:dateCreated | 2002-11-8 | lld:pubmed |
| pubmed-article:12423307 | pubmed:abstractText | T helper 2 (Th2) cytokines [interleukin (IL)-4 and IL-5] play a central role in the development of allergic immune responses. After allergen provocation, the expression of Th2 cytokines is rapidly up-regulated in atopy and asthma. IL-6 is a multifunctional cytokine that is able to direct Th2 immune responses and is secreted by multiple tissue cell types. This study shows that IL-6 induces up-regulation of IL-4 and IL-5 after short (5 min) preincubation periods in freshly isolated, alpha-CD3/alpha-CD28-stimulated T cells. After longer preincubation periods with IL-6 (12 and 24 hr), the priming effect on IL-4 production gradually disappears, whereas the effect on IL-5 becomes more pronounced. In contrast, a small but significant inhibitory effect is found on the production of the Th1 cytokine interferon-gamma. Additional experiments indicate that the long-term priming effect of IL-6 on IL-5 production is dependent on IL-2 signalling. This is not the case for the short-term IL-6 effect on IL-5 secretion, where the p38 mitogen-activated protein kinase-dependent induction of activator protein-1 DNA-binding activity is involved, independent of signal transducer and activator of transcription 3 phosphorylation. In summary, these data demonstrate that the short-term and long-term priming effects of IL-6 on Th2 cytokine production are regulated by different mechanisms. | lld:pubmed |
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| pubmed-article:12423307 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12423307 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12423307 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12423307 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12423307 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12423307 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12423307 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:12423307 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:12423307 | pubmed:author | pubmed-author:PostmaDirkje... | lld:pubmed |
| pubmed-article:12423307 | pubmed:author | pubmed-author:de... | lld:pubmed |
| pubmed-article:12423307 | pubmed:author | pubmed-author:KauffmanHenk... | lld:pubmed |
| pubmed-article:12423307 | pubmed:author | pubmed-author:VellengaEdoE | lld:pubmed |
| pubmed-article:12423307 | pubmed:author | pubmed-author:HeijinkIrene... | lld:pubmed |
| pubmed-article:12423307 | pubmed:author | pubmed-author:BorgerPeterP | lld:pubmed |
| pubmed-article:12423307 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12423307 | pubmed:volume | 107 | lld:pubmed |
| pubmed-article:12423307 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12423307 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12423307 | pubmed:pagination | 316-24 | lld:pubmed |
| pubmed-article:12423307 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:12423307 | pubmed:meshHeading | pubmed-meshheading:12423307... | lld:pubmed |
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| pubmed-article:12423307 | pubmed:meshHeading | pubmed-meshheading:12423307... | lld:pubmed |
| pubmed-article:12423307 | pubmed:meshHeading | pubmed-meshheading:12423307... | lld:pubmed |
| pubmed-article:12423307 | pubmed:meshHeading | pubmed-meshheading:12423307... | lld:pubmed |
| pubmed-article:12423307 | pubmed:meshHeading | pubmed-meshheading:12423307... | lld:pubmed |
| pubmed-article:12423307 | pubmed:meshHeading | pubmed-meshheading:12423307... | lld:pubmed |
| pubmed-article:12423307 | pubmed:meshHeading | pubmed-meshheading:12423307... | lld:pubmed |
| pubmed-article:12423307 | pubmed:meshHeading | pubmed-meshheading:12423307... | lld:pubmed |
| pubmed-article:12423307 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12423307 | pubmed:articleTitle | Interleukin-6 promotes the production of interleukin-4 and interleukin-5 by interleukin-2-dependent and -independent mechanisms in freshly isolated human T cells. | lld:pubmed |
| pubmed-article:12423307 | pubmed:affiliation | Department of Allergology, University Hospital Groningen, Hanzeplein 1, NL-9713 GZ Groningen, the Netherlands. | lld:pubmed |
| pubmed-article:12423307 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12423307 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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