| pubmed-article:12419371 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12419371 | lifeskim:mentions | umls-concept:C0003308 | lld:lifeskim |
| pubmed-article:12419371 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:12419371 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:12419371 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:12419371 | lifeskim:mentions | umls-concept:C0762202 | lld:lifeskim |
| pubmed-article:12419371 | lifeskim:mentions | umls-concept:C0243072 | lld:lifeskim |
| pubmed-article:12419371 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:12419371 | pubmed:dateCreated | 2002-11-6 | lld:pubmed |
| pubmed-article:12419371 | pubmed:abstractText | Core-modified sordaricin derivatives were prepared via biotransformation followed by chemical modification and tested for antifungal activity. The antifungal activity proved to be very sensitive to modifications in the sterics and/or lipophilicity of the diterpene skeleton. Introduction of polar groups such as hydroxyl in the diterpene core results in loss of potency while small and lipophilic groups such as fluorine and the 7,8-olefin are well tolerated. | lld:pubmed |
| pubmed-article:12419371 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12419371 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12419371 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12419371 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12419371 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12419371 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12419371 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12419371 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:12419371 | pubmed:issn | 0960-894X | lld:pubmed |
| pubmed-article:12419371 | pubmed:author | pubmed-author:HuangStellaS | lld:pubmed |
| pubmed-article:12419371 | pubmed:author | pubmed-author:ChenYijunY | lld:pubmed |
| pubmed-article:12419371 | pubmed:author | pubmed-author:MazzuccoCharl... | lld:pubmed |
| pubmed-article:12419371 | pubmed:author | pubmed-author:StickleTerry... | lld:pubmed |
| pubmed-article:12419371 | pubmed:author | pubmed-author:VyasDolatrai... | lld:pubmed |
| pubmed-article:12419371 | pubmed:author | pubmed-author:Balasubramani... | lld:pubmed |
| pubmed-article:12419371 | pubmed:author | pubmed-author:MatsonJames... | lld:pubmed |
| pubmed-article:12419371 | pubmed:author | pubmed-author:Regueiro-RenA... | lld:pubmed |
| pubmed-article:12419371 | pubmed:author | pubmed-author:CarrollTina... | lld:pubmed |
| pubmed-article:12419371 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12419371 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:12419371 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:12419371 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12419371 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12419371 | pubmed:pagination | 3403-5 | lld:pubmed |
| pubmed-article:12419371 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:12419371 | pubmed:meshHeading | pubmed-meshheading:12419371... | lld:pubmed |
| pubmed-article:12419371 | pubmed:meshHeading | pubmed-meshheading:12419371... | lld:pubmed |
| pubmed-article:12419371 | pubmed:meshHeading | pubmed-meshheading:12419371... | lld:pubmed |
| pubmed-article:12419371 | pubmed:meshHeading | pubmed-meshheading:12419371... | lld:pubmed |
| pubmed-article:12419371 | pubmed:meshHeading | pubmed-meshheading:12419371... | lld:pubmed |
| pubmed-article:12419371 | pubmed:meshHeading | pubmed-meshheading:12419371... | lld:pubmed |
| pubmed-article:12419371 | pubmed:meshHeading | pubmed-meshheading:12419371... | lld:pubmed |
| pubmed-article:12419371 | pubmed:meshHeading | pubmed-meshheading:12419371... | lld:pubmed |
| pubmed-article:12419371 | pubmed:meshHeading | pubmed-meshheading:12419371... | lld:pubmed |
| pubmed-article:12419371 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12419371 | pubmed:articleTitle | Core-modified sordaricin derivatives: synthesis and antifungal activity. | lld:pubmed |
| pubmed-article:12419371 | pubmed:affiliation | Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 06492, USA. alicia.regueiroren@bms.com | lld:pubmed |
| pubmed-article:12419371 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:12419371 | lld:chembl |
