| pubmed-article:12409978 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12409978 | lifeskim:mentions | umls-concept:C0003018 | lld:lifeskim |
| pubmed-article:12409978 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:12409978 | lifeskim:mentions | umls-concept:C0103306 | lld:lifeskim |
| pubmed-article:12409978 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:12409978 | pubmed:dateCreated | 2002-10-31 | lld:pubmed |
| pubmed-article:12409978 | pubmed:abstractText | The inhibitory effects of angiotensin-(1-7) on angiotensin II-induced vasoconstriction, growth of vascular smooth muscle cells, stimulation of protein kinase C, extracellular signal-regulated kinases (ERK), and angiotensin subtype 1 receptor (AT1) and subtype 2 receptor (AT2) mRNA expression were investigated. The hemodynamic effects of angiotensin-(1-7) were measured in Wistar rats. Vasoconstriction was measured using aortic rings. DNA synthesis or protein synthesis was measured in cultured vascular smooth muscle cells using [3H] thymidine or [3H] leucine incorporation, respectively. Angiotensin II stimulated protein kinase C and ERK1/2 were measured by Western blot analysis using phosphospecific protein kinase C and ERK1/2 antibodies. AT1 and AT2 receptor mRNA expression was measured using reverse-transcription polymerase chain reaction. Infusion of angiotensin II significantly increased whereas infusion of angiotensin-(1-7) had no effects on mean arterial blood pressure in Wistar rats. Angiotensin-(1-7) dose-dependently showed partial antagonism on angiotensin II-induced contraction of aortic rings. Angiotensin-(1-7) showed partial antagonism on angiotensin II-induced DNA synthesis and protein synthesis. Angiotensin-(1-7) showed partial antagonism on angiotensin II-induced activation of protein kinase C and ERK1/2. The administration of angiotensin-(1-7) showed partial antagonism on angiotensin II-induced downregulation of AT1 receptor mRNA expression, whereas AT2 receptor mRNA expression was unchanged. Angiotensin-(1-7) showed partial antagonism on angiotensin II-induced intracellular signal transduction and may play a crucial role in the adaptation process of AT1 receptors to sustained stimulation of angiotensin II. | lld:pubmed |
| pubmed-article:12409978 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12409978 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12409978 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12409978 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12409978 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12409978 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12409978 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12409978 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12409978 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12409978 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12409978 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12409978 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:12409978 | pubmed:issn | 0160-2446 | lld:pubmed |
| pubmed-article:12409978 | pubmed:author | pubmed-author:ZhuZhimingZ | lld:pubmed |
| pubmed-article:12409978 | pubmed:author | pubmed-author:ZhuShanjunS | lld:pubmed |
| pubmed-article:12409978 | pubmed:author | pubmed-author:TepelMartinM | lld:pubmed |
| pubmed-article:12409978 | pubmed:author | pubmed-author:ZhongJianJ | lld:pubmed |
| pubmed-article:12409978 | pubmed:author | pubmed-author:LiuDaoyanD | lld:pubmed |
| pubmed-article:12409978 | pubmed:author | pubmed-author:Van Der... | lld:pubmed |
| pubmed-article:12409978 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12409978 | pubmed:volume | 40 | lld:pubmed |
| pubmed-article:12409978 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12409978 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12409978 | pubmed:pagination | 693-700 | lld:pubmed |
| pubmed-article:12409978 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:12409978 | pubmed:meshHeading | pubmed-meshheading:12409978... | lld:pubmed |
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| pubmed-article:12409978 | pubmed:meshHeading | pubmed-meshheading:12409978... | lld:pubmed |
| pubmed-article:12409978 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12409978 | pubmed:articleTitle | Angiotensin-(1-7) inhibits angiotensin II-induced signal transduction. | lld:pubmed |
| pubmed-article:12409978 | pubmed:affiliation | Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing, Peoples Republic of China. zhuzm@cta.cq.cn | lld:pubmed |
| pubmed-article:12409978 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12409978 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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