| pubmed-article:12394422 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12394422 | lifeskim:mentions | umls-concept:C0025611 | lld:lifeskim |
| pubmed-article:12394422 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:12394422 | lifeskim:mentions | umls-concept:C0012632 | lld:lifeskim |
| pubmed-article:12394422 | lifeskim:mentions | umls-concept:C0680242 | lld:lifeskim |
| pubmed-article:12394422 | lifeskim:mentions | umls-concept:C0201734 | lld:lifeskim |
| pubmed-article:12394422 | pubmed:issue | 5-6 | lld:pubmed |
| pubmed-article:12394422 | pubmed:dateCreated | 2002-10-23 | lld:pubmed |
| pubmed-article:12394422 | pubmed:abstractText | Animals were trained to discriminate 5 or 10 mg/kg cocaine (rats), or 3 mg/kg (+)-amphetamine (pigeons) from saline, after which dose-response curves were determined for (+)-methamphetamine and other drugs before and after administration of a (+)-methamphetamine-specific monoclonal antibody (K(D) =250 nM). In rats trained to discriminate 10 mg/kg cocaine from saline, intravenous (+)-methamphetamine was about three times more potent as a discriminative stimulus than intraperitoneal (+)-methamphetamine. Also in these rats, intraperitoneal (+)-methamphetamine and (+)-amphetamine were about equipotent as discriminative stimuli, and were about three times more potent than intraperitoneal cocaine. In pigeons trained to discriminate 3 mg/kg intramuscular (i.m.) (+)-amphetamine from saline, (+)-methamphetamine and (+)-amphetamine were nearly equipotent, while cocaine was slightly less potent. In rats trained to discriminate 5 or 10 mg/kg cocaine from saline, intravenous administration of 1 g/kg of the antibody shifted both intravenous and intraperitoneal dose-response curves for (+)-methamphetamine discrimination approximately threefold to the right at 1 or 4 days after administration of the antibody. In pigeons trained to discriminate 3 mg/kg intramuscular (+)-amphetamine from saline, a similar shift of the (+)-methamphetamine dose-response curve to the right also lasted for 4-7 days. However, the antibody did not affect the (+)-amphetamine dose-response curve (pigeons), or the cocaine (rats) dose-response curve. The data show that a low affinity anti-(+)-methamphetamine-specific antibody can produce a specific antagonism of an effect of (+)-methamphetamine that is closely associated with its abuse. | lld:pubmed |
| pubmed-article:12394422 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12394422 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12394422 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12394422 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12394422 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12394422 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12394422 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12394422 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12394422 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12394422 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12394422 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:12394422 | pubmed:issn | 0955-8810 | lld:pubmed |
| pubmed-article:12394422 | pubmed:author | pubmed-author:McMillanD EDE | lld:pubmed |
| pubmed-article:12394422 | pubmed:author | pubmed-author:HardwickW CWC | lld:pubmed |
| pubmed-article:12394422 | pubmed:author | pubmed-author:OwensS MSM | lld:pubmed |
| pubmed-article:12394422 | pubmed:author | pubmed-author:LiMiM | lld:pubmed |
| pubmed-article:12394422 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12394422 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:12394422 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12394422 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12394422 | pubmed:pagination | 465-73 | lld:pubmed |
| pubmed-article:12394422 | pubmed:dateRevised | 2009-7-7 | lld:pubmed |
| pubmed-article:12394422 | pubmed:meshHeading | pubmed-meshheading:12394422... | lld:pubmed |
| pubmed-article:12394422 | pubmed:meshHeading | pubmed-meshheading:12394422... | lld:pubmed |
| pubmed-article:12394422 | pubmed:meshHeading | pubmed-meshheading:12394422... | lld:pubmed |
| pubmed-article:12394422 | pubmed:meshHeading | pubmed-meshheading:12394422... | lld:pubmed |
| pubmed-article:12394422 | pubmed:meshHeading | pubmed-meshheading:12394422... | lld:pubmed |
| pubmed-article:12394422 | pubmed:meshHeading | pubmed-meshheading:12394422... | lld:pubmed |
| pubmed-article:12394422 | pubmed:meshHeading | pubmed-meshheading:12394422... | lld:pubmed |
| pubmed-article:12394422 | pubmed:meshHeading | pubmed-meshheading:12394422... | lld:pubmed |
| pubmed-article:12394422 | pubmed:meshHeading | pubmed-meshheading:12394422... | lld:pubmed |
| pubmed-article:12394422 | pubmed:meshHeading | pubmed-meshheading:12394422... | lld:pubmed |
| pubmed-article:12394422 | pubmed:meshHeading | pubmed-meshheading:12394422... | lld:pubmed |
| pubmed-article:12394422 | pubmed:meshHeading | pubmed-meshheading:12394422... | lld:pubmed |
| pubmed-article:12394422 | pubmed:meshHeading | pubmed-meshheading:12394422... | lld:pubmed |
| pubmed-article:12394422 | pubmed:meshHeading | pubmed-meshheading:12394422... | lld:pubmed |
| pubmed-article:12394422 | pubmed:meshHeading | pubmed-meshheading:12394422... | lld:pubmed |
| pubmed-article:12394422 | pubmed:meshHeading | pubmed-meshheading:12394422... | lld:pubmed |
| pubmed-article:12394422 | pubmed:meshHeading | pubmed-meshheading:12394422... | lld:pubmed |
| pubmed-article:12394422 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12394422 | pubmed:articleTitle | Pharmacokinetic antagonism of (+)-methamphetamine discrimination by a low-affinity monoclonal anti-methamphetamine antibody. | lld:pubmed |
| pubmed-article:12394422 | pubmed:affiliation | Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, 72205, USA. McMillanDonaldE@uams.edu | lld:pubmed |
| pubmed-article:12394422 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12394422 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12394422 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12394422 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12394422 | lld:pubmed |
