| pubmed-article:12393617 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12393617 | lifeskim:mentions | umls-concept:C0254610 | lld:lifeskim |
| pubmed-article:12393617 | lifeskim:mentions | umls-concept:C0022688 | lld:lifeskim |
| pubmed-article:12393617 | lifeskim:mentions | umls-concept:C0038952 | lld:lifeskim |
| pubmed-article:12393617 | lifeskim:mentions | umls-concept:C0439857 | lld:lifeskim |
| pubmed-article:12393617 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:12393617 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:12393617 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:12393617 | pubmed:dateCreated | 2002-11-4 | lld:pubmed |
| pubmed-article:12393617 | pubmed:abstractText | Cellular homeostasis requires a balance between cell production, cell survival, and cell death. Production of natural killer (NK) cells from bone marrow precursor cells requires interleukin 15 (IL-15); however, very little is known about the factors controlling survival of mature NK cells in vivo. Because mice deficient in IL-15 (IL-15(-/-) mice) fail to develop NK cells, it is not known whether mature NK cells can survive in an environment lacking IL-15. We hypothesized that IL-15 might indeed be required for survival of mature NK cells in vivo. Freshly isolated NK cells labeled with 5-(and-6)-carboxyfluorescein diacetate, succinimidyl ester (CFSE) were adoptively transferred into IL-15(-/-) mice and littermate control (IL-15(+/-)) mice. Within 36 hours after transfer, NK cells were detected in both IL-15(-/-) and IL-15(+/-) mice; however, significantly more (P <.003) CFSE-positive (CFSE(+)) NK cells were found in control mice than in IL-15(-/-) mice. By 5 days, similar numbers of CFSE(+) NK cells were still easily detected in IL-15(+/-) mice, whereas no CFSE(+) NK cells survived in IL-15(-/-) mice. Furthermore, mice with severe combined immunodeficiency treated with the Fab fragment of a blocking antibody recognizing a signaling subunit of the IL-15 receptor, IL-2/15Rbeta, had a significant ( approximately 90%) loss of NK cells compared with control mice. Finally, NK cells from Bcl-2 transgenic mice that were adoptively transferred into IL-15(-/-) mice did survive. These results show conclusively that IL-15 is required for mature NK cell survival in vivo and suggest that IL-15 mediates its effect on NK cell survival by means of Bcl-2. | lld:pubmed |
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| pubmed-article:12393617 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12393617 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12393617 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:12393617 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12393617 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12393617 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:12393617 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:12393617 | pubmed:author | pubmed-author:VoasRR | lld:pubmed |
| pubmed-article:12393617 | pubmed:author | pubmed-author:CaligiuriMich... | lld:pubmed |
| pubmed-article:12393617 | pubmed:author | pubmed-author:FehnigerTodd... | lld:pubmed |
| pubmed-article:12393617 | pubmed:author | pubmed-author:CooperMegan... | lld:pubmed |
| pubmed-article:12393617 | pubmed:author | pubmed-author:BushJennifer... | lld:pubmed |
| pubmed-article:12393617 | pubmed:author | pubmed-author:VanDeusenJeff... | lld:pubmed |
| pubmed-article:12393617 | pubmed:author | pubmed-author:WaiteRoss ERE | lld:pubmed |
| pubmed-article:12393617 | pubmed:author | pubmed-author:AguilaHector... | lld:pubmed |
| pubmed-article:12393617 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12393617 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:12393617 | pubmed:volume | 100 | lld:pubmed |
| pubmed-article:12393617 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12393617 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12393617 | pubmed:pagination | 3633-8 | lld:pubmed |
| pubmed-article:12393617 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:12393617 | pubmed:meshHeading | pubmed-meshheading:12393617... | lld:pubmed |
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| pubmed-article:12393617 | pubmed:meshHeading | pubmed-meshheading:12393617... | lld:pubmed |
| pubmed-article:12393617 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12393617 | pubmed:articleTitle | In vivo evidence for a dependence on interleukin 15 for survival of natural killer cells. | lld:pubmed |
| pubmed-article:12393617 | pubmed:affiliation | Department of Internal Medicine, Division of Hematology/Oncology, The James Cancer Hospital and Comprehensive Cancer Center, The Ohio State University, Columbus 43210, USA. | lld:pubmed |
| pubmed-article:12393617 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12393617 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12393617 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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