| pubmed-article:12393409 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12393409 | lifeskim:mentions | umls-concept:C1332399 | lld:lifeskim |
| pubmed-article:12393409 | lifeskim:mentions | umls-concept:C1333064 | lld:lifeskim |
| pubmed-article:12393409 | lifeskim:mentions | umls-concept:C2745955 | lld:lifeskim |
| pubmed-article:12393409 | lifeskim:mentions | umls-concept:C2239290 | lld:lifeskim |
| pubmed-article:12393409 | lifeskim:mentions | umls-concept:C1511695 | lld:lifeskim |
| pubmed-article:12393409 | lifeskim:mentions | umls-concept:C0332183 | lld:lifeskim |
| pubmed-article:12393409 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:12393409 | pubmed:dateCreated | 2003-1-1 | lld:pubmed |
| pubmed-article:12393409 | pubmed:abstractText | We studied the genomic status of BCL6 in 23 cases of nodular lymphocyte predominance Hodgkin lymphoma (NLPHL) and 40 cases of classical Hodgkin lymphoma (cHL), using dual-color interphase fluorescence in situ hybridization (FISH). The BCL6 rearrangement was identified in 48% of NLPHL cases and was not detected in cHL cases. As a confirmation, sequential or simultaneous immunohistochemistry (IHC) and FISH using CD20 or BCL6 antibodies and BCL6 DNA probes was performed in 8 NLPHL cases. The BCL6-associated translocations, t(3;22)(q27;q11), t(3;7)(q27;p12), and the most probable t(3;9)(q27;p13), were identified in 3 cases. A consistent expression of BCL6 protein in popcorn cells with the highest number of intensely stained cells in cases with a genomic BCL6 rearrangement was shown by IHC. These findings support the hypothesis of a germinal center B cell-derived origin of NLPHL, indicate a significant role of BCL6 in the pathogenesis of NLPHL, and provide further evidence of the genetic diversity underlying the pathogenesis of NLPHL and cHL. | lld:pubmed |
| pubmed-article:12393409 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12393409 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12393409 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:12393409 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12393409 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:12393409 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:12393409 | pubmed:author | pubmed-author:WlodarskaIwon... | lld:pubmed |
| pubmed-article:12393409 | pubmed:author | pubmed-author:De... | lld:pubmed |
| pubmed-article:12393409 | pubmed:author | pubmed-author:PauwelsPatric... | lld:pubmed |
| pubmed-article:12393409 | pubmed:author | pubmed-author:HagemeijerAnn... | lld:pubmed |
| pubmed-article:12393409 | pubmed:author | pubmed-author:SiebertReiner... | lld:pubmed |
| pubmed-article:12393409 | pubmed:author | pubmed-author:MaesBrigitteB | lld:pubmed |
| pubmed-article:12393409 | pubmed:author | pubmed-author:NooyenPeetP | lld:pubmed |
| pubmed-article:12393409 | pubmed:author | pubmed-author:Martin-Subero... | lld:pubmed |
| pubmed-article:12393409 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12393409 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:12393409 | pubmed:volume | 101 | lld:pubmed |
| pubmed-article:12393409 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12393409 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12393409 | pubmed:pagination | 706-10 | lld:pubmed |
| pubmed-article:12393409 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:12393409 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12393409 | pubmed:articleTitle | Frequent occurrence of BCL6 rearrangements in nodular lymphocyte predominance Hodgkin lymphoma but not in classical Hodgkin lymphoma. | lld:pubmed |
| pubmed-article:12393409 | pubmed:affiliation | Center for Human Genetics, Catholic University of Leuven, Belgium. | lld:pubmed |
| pubmed-article:12393409 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12393409 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:604 | entrezgene:pubmed | pubmed-article:12393409 | lld:entrezgene |
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