| pubmed-article:12379849 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12379849 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:12379849 | lifeskim:mentions | umls-concept:C0085298 | lld:lifeskim |
| pubmed-article:12379849 | lifeskim:mentions | umls-concept:C0521451 | lld:lifeskim |
| pubmed-article:12379849 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:12379849 | lifeskim:mentions | umls-concept:C0011155 | lld:lifeskim |
| pubmed-article:12379849 | lifeskim:mentions | umls-concept:C1417099 | lld:lifeskim |
| pubmed-article:12379849 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:12379849 | pubmed:dateCreated | 2002-11-4 | lld:pubmed |
| pubmed-article:12379849 | pubmed:abstractText | The four MEF2 transcription factors (MEF2A, -B, -C, and -D) regulate differentiation and calcium-dependent gene expression in muscle cells. We generated mice deficient in MEF2A, the predominant Mef2 gene product expressed in post-natal cardiac muscle. Most mice lacking Mef2a died suddenly within the first week of life and exhibited pronounced dilation of the right ventricle, myofibrillar fragmentation, mitochondrial disorganization and activation of a fetal cardiac gene program. The few Mef2a(-/-) mice that survived to adulthood also showed a deficiency of cardiac mitochondria and susceptibility to sudden death. Paradoxically, MEF2 transcriptional activity, revealed by the expression of a MEF2-dependent transgene, was enhanced in the hearts of Mef2a-mutant mice, reflecting the transcriptional activation of residual MEF2D. These findings reveal specific roles for MEF2A in maintaining appropriate mitochondrial content and cyto-architectural integrity in the post-natal heart and show that other MEF2 isoforms cannot support these activities. | lld:pubmed |
| pubmed-article:12379849 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12379849 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12379849 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12379849 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12379849 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:12379849 | pubmed:issn | 1078-8956 | lld:pubmed |
| pubmed-article:12379849 | pubmed:author | pubmed-author:EnkLL | lld:pubmed |
| pubmed-article:12379849 | pubmed:author | pubmed-author:RichardsonJam... | lld:pubmed |
| pubmed-article:12379849 | pubmed:author | pubmed-author:OlsonEric NEN | lld:pubmed |
| pubmed-article:12379849 | pubmed:author | pubmed-author:HillJoseph... | lld:pubmed |
| pubmed-article:12379849 | pubmed:author | pubmed-author:Bassel-DubyRh... | lld:pubmed |
| pubmed-article:12379849 | pubmed:author | pubmed-author:BlackBrian... | lld:pubmed |
| pubmed-article:12379849 | pubmed:author | pubmed-author:NayaFrancisco... | lld:pubmed |
| pubmed-article:12379849 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12379849 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:12379849 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12379849 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12379849 | pubmed:pagination | 1303-9 | lld:pubmed |
| pubmed-article:12379849 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12379849 | pubmed:meshHeading | pubmed-meshheading:12379849... | lld:pubmed |
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| pubmed-article:12379849 | pubmed:meshHeading | pubmed-meshheading:12379849... | lld:pubmed |
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| pubmed-article:12379849 | pubmed:meshHeading | pubmed-meshheading:12379849... | lld:pubmed |
| pubmed-article:12379849 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12379849 | pubmed:articleTitle | Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factor. | lld:pubmed |
| pubmed-article:12379849 | pubmed:affiliation | Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA. | lld:pubmed |
| pubmed-article:12379849 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12379849 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12379849 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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