| pubmed-article:12376092 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12376092 | lifeskim:mentions | umls-concept:C1511726 | lld:lifeskim |
| pubmed-article:12376092 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:12376092 | lifeskim:mentions | umls-concept:C2347947 | lld:lifeskim |
| pubmed-article:12376092 | lifeskim:mentions | umls-concept:C1709016 | lld:lifeskim |
| pubmed-article:12376092 | lifeskim:mentions | umls-concept:C0525060 | lld:lifeskim |
| pubmed-article:12376092 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:12376092 | pubmed:dateCreated | 2002-10-11 | lld:pubmed |
| pubmed-article:12376092 | pubmed:abstractText | Large-scale gene expression profiling with DNA microarrays opens new dimensions to molecular biology but still lacks the overall precision of traditional low-scale techniques. We developed a novel strategy of data processing linking search stringency to quality indicators for efficient detection of low-level, regulated genes. Using retinoid-induced differentiation of NB-4 promyelocytic cells, the variation of expression profiles between biological duplicates was studied and compared with the changes induced by all-trans retinoic acid (atRA) treatment. An analysis of 4320 genes showed that retinoic acid has mainly geneactivating function in NB-4 cells. Treatment with atRA for 18 hours induced metabolic genes that may be associated with cell differentiation and signaling factors triggering later events leading to apoptosis; cytokine genes were among the highest stimulated by atRA. Notably, we identified a regulatory loop inhibiting MYC action: as MYC was downregulated, a cognate repressor of MYC was upregulated. | lld:pubmed |
| pubmed-article:12376092 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12376092 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12376092 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12376092 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12376092 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:12376092 | pubmed:issn | 0888-7543 | lld:pubmed |
| pubmed-article:12376092 | pubmed:author | pubmed-author:GronemeyerHin... | lld:pubmed |
| pubmed-article:12376092 | pubmed:author | pubmed-author:Raffelsberger... | lld:pubmed |
| pubmed-article:12376092 | pubmed:author | pubmed-author:DembéléDoulay... | lld:pubmed |
| pubmed-article:12376092 | pubmed:author | pubmed-author:NeubauerMike... | lld:pubmed |
| pubmed-article:12376092 | pubmed:author | pubmed-author:GottardisMarc... | lld:pubmed |
| pubmed-article:12376092 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12376092 | pubmed:volume | 80 | lld:pubmed |
| pubmed-article:12376092 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12376092 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12376092 | pubmed:pagination | 385-94 | lld:pubmed |
| pubmed-article:12376092 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12376092 | pubmed:meshHeading | pubmed-meshheading:12376092... | lld:pubmed |
| pubmed-article:12376092 | pubmed:meshHeading | pubmed-meshheading:12376092... | lld:pubmed |
| pubmed-article:12376092 | pubmed:meshHeading | pubmed-meshheading:12376092... | lld:pubmed |
| pubmed-article:12376092 | pubmed:meshHeading | pubmed-meshheading:12376092... | lld:pubmed |
| pubmed-article:12376092 | pubmed:meshHeading | pubmed-meshheading:12376092... | lld:pubmed |
| pubmed-article:12376092 | pubmed:meshHeading | pubmed-meshheading:12376092... | lld:pubmed |
| pubmed-article:12376092 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12376092 | pubmed:articleTitle | Quality indicators increase the reliability of microarray data. | lld:pubmed |
| pubmed-article:12376092 | pubmed:affiliation | Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, B.P. 10142, C. U. de Strasbourg, France. | lld:pubmed |
| pubmed-article:12376092 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12376092 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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