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pubmed-article:12360193pubmed:abstractTextMembers of the structural maintenance of chromosomes (SMC) family share a characteristic design and configuration of protein domains that provides the molecular basis for the various functions of this family in chromosome dynamics. SMC proteins have a role in chromosome condensation, sister-chromatid cohesion, DNA repair and recombination, and gene dosage compensation, and they function in somatic and meiotic cells. As more is learned about how their unique design affects their function, a picture of a dynamic and varied protein family is emerging.lld:pubmed
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pubmed-article:12360193pubmed:articleTitleThe many functions of SMC proteins in chromosome dynamics.lld:pubmed
pubmed-article:12360193pubmed:affiliationThe Carl C. Icahn Institute for Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York 10029, USA. rolf.jessberger@mssm.edulld:pubmed
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