| pubmed-article:12351377 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12351377 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:12351377 | lifeskim:mentions | umls-concept:C1556084 | lld:lifeskim |
| pubmed-article:12351377 | lifeskim:mentions | umls-concept:C0023467 | lld:lifeskim |
| pubmed-article:12351377 | lifeskim:mentions | umls-concept:C0085669 | lld:lifeskim |
| pubmed-article:12351377 | lifeskim:mentions | umls-concept:C1511473 | lld:lifeskim |
| pubmed-article:12351377 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:12351377 | lifeskim:mentions | umls-concept:C0237881 | lld:lifeskim |
| pubmed-article:12351377 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:12351377 | lifeskim:mentions | umls-concept:C0220901 | lld:lifeskim |
| pubmed-article:12351377 | lifeskim:mentions | umls-concept:C0750502 | lld:lifeskim |
| pubmed-article:12351377 | lifeskim:mentions | umls-concept:C1515568 | lld:lifeskim |
| pubmed-article:12351377 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:12351377 | pubmed:dateCreated | 2002-9-27 | lld:pubmed |
| pubmed-article:12351377 | pubmed:abstractText | The transcription factor C/EBPalpha is crucial for differentiation of mature granulocytes. Recently, different CEBPA gene mutations likely to induce differentiation arrest have been described in nearly 10% of patients with acute myeloid leukemia (AML). In the present study, we retrospectively analyzed the prognostic significance of CEBPA mutations in 135 AML patients (French-American-British [FAB]-M3 excluded). All patients were prospectively enrolled between 1990 and 1996 in a multicenter trial of the ALFA (Acute Leukemia French Association) Group (median age 45 years, median follow-up 5.7 years). Mutations were assessed using direct sequencing of the CEBPA gene. Twenty-two mutations were found in 15 (11%) of 135 patients tested. Twelve patients had at least one mutation located in the N-terminal part of the protein leading to the lack of expression of the full-length C/EBPalpha protein. CEBPA mutations were present only in patients belonging to the intermediate cytogenetic risk subgroup and associated with the FAB-M1 subtype (P =.02). FLT3 internal tandem duplication (ITD) was found in 5 of 15 CEBPA-mutated as compared with 30 of 119 CEBPA-nonmutated cases tested (P =.54). Presence of CEBPA mutations was identified as an independent good prognosis factor for outcome even after adjustment on cytogenetics and FLT3 status (estimated 5-year overall survival 53% vs 25%, P =.04). FLT3-ITD appeared to act as a major bad prognosis factor in patients with CEBPA-mutated AML. We thus propose a risk classification that includes in the favorable subgroup all patients from the intermediate subgroup displaying CEBPA mutations when not associated with FLT3-ITD. | lld:pubmed |
| pubmed-article:12351377 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12351377 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12351377 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:12351377 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12351377 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12351377 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:12351377 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:12351377 | pubmed:author | pubmed-author:FenauxPierreP | lld:pubmed |
| pubmed-article:12351377 | pubmed:author | pubmed-author:PreudhommeCla... | lld:pubmed |
| pubmed-article:12351377 | pubmed:author | pubmed-author:ThomasXavierX | lld:pubmed |
| pubmed-article:12351377 | pubmed:author | pubmed-author:DombretHervéH | lld:pubmed |
| pubmed-article:12351377 | pubmed:author | pubmed-author:RaffouxEmmanu... | lld:pubmed |
| pubmed-article:12351377 | pubmed:author | pubmed-author:CastaigneSylv... | lld:pubmed |
| pubmed-article:12351377 | pubmed:author | pubmed-author:TigaudIsabell... | lld:pubmed |
| pubmed-article:12351377 | pubmed:author | pubmed-author:de... | lld:pubmed |
| pubmed-article:12351377 | pubmed:author | pubmed-author:CayuelaJean-M... | lld:pubmed |
| pubmed-article:12351377 | pubmed:author | pubmed-author:SagotChristop... | lld:pubmed |
| pubmed-article:12351377 | pubmed:author | pubmed-author:BoisselNicola... | lld:pubmed |
| pubmed-article:12351377 | pubmed:author | pubmed-author:LamandinCharl... | lld:pubmed |
| pubmed-article:12351377 | pubmed:author | pubmed-author:ALFA Group | lld:pubmed |
| pubmed-article:12351377 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12351377 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:12351377 | pubmed:volume | 100 | lld:pubmed |
| pubmed-article:12351377 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12351377 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12351377 | pubmed:pagination | 2717-23 | lld:pubmed |
| pubmed-article:12351377 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:12351377 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12351377 | pubmed:articleTitle | Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: a study from the Acute Leukemia French Association (ALFA). | lld:pubmed |
| pubmed-article:12351377 | pubmed:affiliation | Département d'Hématologie and INSERM U524, Hôpital Claude Huriez, Lille, France. cpreudhomme@chru-lille.fr | lld:pubmed |
| pubmed-article:12351377 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12351377 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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