Linked Life Data

12242484

Source:http://linkedlifedata.com/resource/pubmed/id/12242484

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pubmed-article:12242484pubmed:abstractTextThe aim of this study was to determine the spatial and temporal expression of various pro-inflammatory cytokines in the peri-sinoatrial nodal area after atrial infarction. Rats were subjected to permanent atrial infarction, in particular, sinoatrial node (SAN) infarction and sacrificed at various time points up to 7 days. Real-time polymerase chain reaction analysis demonstrated that mRNA levels of tumor necrosis factor alpha (TNF-alpha), interleukin-1beta, interleukin-6, and transforming growth factor beta 1 (TGF-beta(1)) were upregulated in the peri-sinoatrial nodal area after atrial infarction. Immunostaining for TNF-alpha and TGF-beta(1) proteins revealed that both cytokines were expressed persistently up to 7 days after atrial infarction around the peri-sinoatrial nodal area. Furthermore, the infiltrating inflammatory cells immunoreactive for both cytokines were predominant within the infarct SAN. In situ hybridization analysis showed that TNF-alpha gene expression was enhanced in the inflammatory cells and myocardium within the peri-sinoatrial nodal area in response to the infarction. These results provide evidence for the local expression of cytokines in the post-ischemic peri-sinoatrial nodal area, suggesting that the upregulation of the cytokines might be associated with the atrial arrhythmia observed after acute myocardial infarction.lld:pubmed
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pubmed-article:12242484pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:12242484pubmed:year2002lld:pubmed
pubmed-article:12242484pubmed:articleTitleInduction of cytokine expression in rat post-ischemic sinoatrial node (SAN).lld:pubmed
pubmed-article:12242484pubmed:affiliationDepartment of Anatomy, Faculty of Medicine, National University of Singapore, Lower Kent Ridge Road, Singapore 117597.lld:pubmed
pubmed-article:12242484pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12242484pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed