| pubmed-article:12236813 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12236813 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:12236813 | lifeskim:mentions | umls-concept:C1705526 | lld:lifeskim |
| pubmed-article:12236813 | lifeskim:mentions | umls-concept:C0232910 | lld:lifeskim |
| pubmed-article:12236813 | lifeskim:mentions | umls-concept:C0521457 | lld:lifeskim |
| pubmed-article:12236813 | lifeskim:mentions | umls-concept:C0332157 | lld:lifeskim |
| pubmed-article:12236813 | lifeskim:mentions | umls-concept:C0851346 | lld:lifeskim |
| pubmed-article:12236813 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:12236813 | lifeskim:mentions | umls-concept:C0332152 | lld:lifeskim |
| pubmed-article:12236813 | lifeskim:mentions | umls-concept:C0079419 | lld:lifeskim |
| pubmed-article:12236813 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:12236813 | pubmed:dateCreated | 2002-9-18 | lld:pubmed |
| pubmed-article:12236813 | pubmed:abstractText | Teratogenesis in tails and limb digits of fetal mice with varying Trp53 status was examined after exposure of pregnant females to 4 Gy gamma radiation with and without a prior 30-cGy exposure. Prior low-dose exposure modified the teratogenic effects of radiation in a manner dependent upon Trp53 status and gestation time. A 4-Gy exposure on gestation day 11 resulted in tail shortening and digit abnormalities. A 30-cGy exposure 24 h prior to a 4-Gy radiation exposure on day 11 reduced the extent of both digit abnormalities and the tail-shortening effects in Trp53(+/+) fetuses and also reduced tail shortening in Trp53(+/-) fetuses, but to a lesser extent. However, the pre-exposure enhanced the tail-shortening effects of 4 Gy in Trp53(-/-) fetuses. In contrast, a 30-cGy exposure given 24 h prior to a 4-Gy exposure on gestation day 12 had no effect on the reduced tail length resulting from the 4-Gy exposure of Trp53(+/+) or Trp53(+/-) fetuses, but it partly protected Trp53(-/-) fetuses against reduced tail length. A 4-Gy exposure alone on day 12 did not result in any increase in the frequency of digit abnormalities in Trp53(-/-) fetuses so any protective effect of the preirradiation could not be detected. However, the preirradiation did result in protection against in digit abnormalities in Trp53(+/-) fetuses. We conclude that radiation-induced teratogenesis reflects both Trp53-dependent and independent processes that lead to apoptosis, and these respond differently to prior adapting doses. | lld:pubmed |
| pubmed-article:12236813 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12236813 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12236813 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12236813 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12236813 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12236813 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:12236813 | pubmed:issn | 0033-7587 | lld:pubmed |
| pubmed-article:12236813 | pubmed:author | pubmed-author:BorehamD RDR | lld:pubmed |
| pubmed-article:12236813 | pubmed:author | pubmed-author:MisonouYY | lld:pubmed |
| pubmed-article:12236813 | pubmed:author | pubmed-author:MitchelR E... | lld:pubmed |
| pubmed-article:12236813 | pubmed:author | pubmed-author:DollingJ-AJA | lld:pubmed |
| pubmed-article:12236813 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12236813 | pubmed:volume | 158 | lld:pubmed |
| pubmed-article:12236813 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12236813 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12236813 | pubmed:pagination | 458-63 | lld:pubmed |
| pubmed-article:12236813 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
| pubmed-article:12236813 | pubmed:meshHeading | pubmed-meshheading:12236813... | lld:pubmed |
| pubmed-article:12236813 | pubmed:meshHeading | pubmed-meshheading:12236813... | lld:pubmed |
| pubmed-article:12236813 | pubmed:meshHeading | pubmed-meshheading:12236813... | lld:pubmed |
| pubmed-article:12236813 | pubmed:meshHeading | pubmed-meshheading:12236813... | lld:pubmed |
| pubmed-article:12236813 | pubmed:meshHeading | pubmed-meshheading:12236813... | lld:pubmed |
| pubmed-article:12236813 | pubmed:meshHeading | pubmed-meshheading:12236813... | lld:pubmed |
| pubmed-article:12236813 | pubmed:meshHeading | pubmed-meshheading:12236813... | lld:pubmed |
| pubmed-article:12236813 | pubmed:meshHeading | pubmed-meshheading:12236813... | lld:pubmed |
| pubmed-article:12236813 | pubmed:meshHeading | pubmed-meshheading:12236813... | lld:pubmed |
| pubmed-article:12236813 | pubmed:meshHeading | pubmed-meshheading:12236813... | lld:pubmed |
| pubmed-article:12236813 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12236813 | pubmed:articleTitle | Influence of prior exposure to low-dose adapting radiation on radiation-induced teratogenic effects in fetal mice with varying Trp53 function. | lld:pubmed |
| pubmed-article:12236813 | pubmed:affiliation | Radiation Biology and Health Physics Branch, Atomic Energy of Canada Limited, Chalk River Laboratories, Ontario, K0J 1J0 Canada. mitchelr@aecl.ca | lld:pubmed |
| pubmed-article:12236813 | pubmed:publicationType | Journal Article | lld:pubmed |
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