| pubmed-article:12235206 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12235206 | lifeskim:mentions | umls-concept:C0017296 | lld:lifeskim |
| pubmed-article:12235206 | lifeskim:mentions | umls-concept:C0001688 | lld:lifeskim |
| pubmed-article:12235206 | lifeskim:mentions | umls-concept:C0005847 | lld:lifeskim |
| pubmed-article:12235206 | lifeskim:mentions | umls-concept:C0879626 | lld:lifeskim |
| pubmed-article:12235206 | lifeskim:mentions | umls-concept:C0547040 | lld:lifeskim |
| pubmed-article:12235206 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:12235206 | pubmed:dateCreated | 2002-9-17 | lld:pubmed |
| pubmed-article:12235206 | pubmed:abstractText | Recent work from many laboratories has demonstrated that the vascular endothelial growth factor-C/VEGF-D/VEGFR-3 signaling pathway is crucial for lymphangiogenesis, and that mutations of the Vegfr3 gene are associated with hereditary lymphedema. Furthermore, VEGF-C gene transfer to the skin of mice with lymphedema induced a regeneration of the cutaneous lymphatic vessel network. However, as is the case with VEGF, high levels of VEGF-C cause blood vessel growth and leakiness, resulting in tissue edema. To avoid these blood vascular side effects of VEGF-C, we constructed a viral vector for a VEGFR-3-specific mutant form of VEGF-C (VEGF-C156S) for lymphedema gene therapy. We demonstrate that VEGF-C156S potently induces lymphangiogenesis in transgenic mouse embryos, and when applied via viral gene transfer, in normal and lymphedema mice. Importantly, adenoviral VEGF-C156S lacked the blood vascular side effects of VEGF and VEGF-C adenoviruses. In particular, in the lymphedema mice functional cutaneous lymphatic vessels of normal caliber and morphology were detected after long-term expression of VEGF-C156S via an adeno associated virus. These results have important implications for the development of gene therapy for human lymphedema. | lld:pubmed |
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| pubmed-article:12235206 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12235206 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12235206 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12235206 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12235206 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12235206 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:12235206 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:12235206 | pubmed:author | pubmed-author:Ylä-Herttuala... | lld:pubmed |
| pubmed-article:12235206 | pubmed:author | pubmed-author:KarkkainenMar... | lld:pubmed |
| pubmed-article:12235206 | pubmed:author | pubmed-author:AlitaloKariK | lld:pubmed |
| pubmed-article:12235206 | pubmed:author | pubmed-author:SaaristoAnneA | lld:pubmed |
| pubmed-article:12235206 | pubmed:author | pubmed-author:VeikkolaTanja... | lld:pubmed |
| pubmed-article:12235206 | pubmed:author | pubmed-author:EnholmBerndtB | lld:pubmed |
| pubmed-article:12235206 | pubmed:author | pubmed-author:PajusolaKatri... | lld:pubmed |
| pubmed-article:12235206 | pubmed:author | pubmed-author:BuelerHansrue... | lld:pubmed |
| pubmed-article:12235206 | pubmed:author | pubmed-author:TammelaTuomas... | lld:pubmed |
| pubmed-article:12235206 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12235206 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:12235206 | pubmed:volume | 196 | lld:pubmed |
| pubmed-article:12235206 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12235206 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12235206 | pubmed:pagination | 719-30 | lld:pubmed |
| pubmed-article:12235206 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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