| pubmed-article:12213597 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12213597 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:12213597 | lifeskim:mentions | umls-concept:C0215848 | lld:lifeskim |
| pubmed-article:12213597 | pubmed:issue | 5-6 | lld:pubmed |
| pubmed-article:12213597 | pubmed:dateCreated | 2002-9-5 | lld:pubmed |
| pubmed-article:12213597 | pubmed:abstractText | Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator that functions as a master regulator of O2 homeostasis. HIF-1 target genes encode proteins that increase O2 delivery and mediate adaptive responses to O2 deprivation. HIF-1 activity is regulated by the cellular O2 concentration and by the major growth factor-stimulated signal transduction pathways. In human cancer cells, both intratumoral hypoxia and genetic alterations affecting signal transduction pathways lead to increased HIF-1 activity, which promotes angiogenesis, metabolic adaptation, and other critical aspects of tumor progression. | lld:pubmed |
| pubmed-article:12213597 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12213597 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12213597 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12213597 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12213597 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:12213597 | pubmed:issn | 0006-2952 | lld:pubmed |
| pubmed-article:12213597 | pubmed:author | pubmed-author:SemenzaGreggG | lld:pubmed |
| pubmed-article:12213597 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12213597 | pubmed:volume | 64 | lld:pubmed |
| pubmed-article:12213597 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12213597 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12213597 | pubmed:pagination | 993-8 | lld:pubmed |
| pubmed-article:12213597 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:12213597 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12213597 | pubmed:articleTitle | Signal transduction to hypoxia-inducible factor 1. | lld:pubmed |
| pubmed-article:12213597 | pubmed:affiliation | Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, CMSC-1004, Baltimore, MD 21287-3914, USA. gsemenza@jhmi.edu | lld:pubmed |
| pubmed-article:12213597 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12213597 | pubmed:publicationType | Review | lld:pubmed |
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