| pubmed-article:12198616 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12198616 | lifeskim:mentions | umls-concept:C0319941 | lld:lifeskim |
| pubmed-article:12198616 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:12198616 | lifeskim:mentions | umls-concept:C0109272 | lld:lifeskim |
| pubmed-article:12198616 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:12198616 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:12198616 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:12198616 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:12198616 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:12198616 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:12198616 | lifeskim:mentions | umls-concept:C2003874 | lld:lifeskim |
| pubmed-article:12198616 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:12198616 | pubmed:dateCreated | 2002-8-28 | lld:pubmed |
| pubmed-article:12198616 | pubmed:abstractText | Cells expressing the T cell receptor beta-chain variable region (Vbeta) 6 constitute the majority of T cells responding to the protective domain (F3) of heat-shock protein 60 from Histoplasma capsulatum. This subset of cells exhibits a T helper type 1 (Th1) profile and is pivotal in protection. In this study, additional F3-reactive T cell lines were generated, leading to the discovery of a Th2 line. Vbeta usage by clones was more diverse than has been previously recognized. Nearly all Th2 clones expressed Vbeta8.1/8.2, whereas Th1 clones expressed Vbeta11 or Vbeta6. In adoptive transfer studies, only the Vbeta6(+) Th1 clone prolonged survival; all Th2 clones accelerated mortality. The ameliorative effect of the Vbeta6(+) Th1 clone was abrogated by treatment with monoclonal antibody to interferon-gamma. Neutralization of interleukin-4 reversed the shortened survival of mice to which the Vbeta6(+) Th2 clone was administered. Thus, F3-mediated protection is confined to a defined Vbeta population, but exacerbation of disease is mediated by multiple Vbeta families. | lld:pubmed |
| pubmed-article:12198616 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12198616 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12198616 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12198616 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12198616 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:12198616 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12198616 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12198616 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12198616 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12198616 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:12198616 | pubmed:issn | 0022-1899 | lld:pubmed |
| pubmed-article:12198616 | pubmed:author | pubmed-author:DeepeGeorge... | lld:pubmed |
| pubmed-article:12198616 | pubmed:author | pubmed-author:GibbonsReta... | lld:pubmed |
| pubmed-article:12198616 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12198616 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:12198616 | pubmed:volume | 186 | lld:pubmed |
| pubmed-article:12198616 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12198616 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12198616 | pubmed:pagination | 815-22 | lld:pubmed |
| pubmed-article:12198616 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:12198616 | pubmed:meshHeading | pubmed-meshheading:12198616... | lld:pubmed |
| pubmed-article:12198616 | pubmed:meshHeading | pubmed-meshheading:12198616... | lld:pubmed |
| pubmed-article:12198616 | pubmed:meshHeading | pubmed-meshheading:12198616... | lld:pubmed |
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| pubmed-article:12198616 | pubmed:meshHeading | pubmed-meshheading:12198616... | lld:pubmed |
| pubmed-article:12198616 | pubmed:meshHeading | pubmed-meshheading:12198616... | lld:pubmed |
| pubmed-article:12198616 | pubmed:meshHeading | pubmed-meshheading:12198616... | lld:pubmed |
| pubmed-article:12198616 | pubmed:meshHeading | pubmed-meshheading:12198616... | lld:pubmed |
| pubmed-article:12198616 | pubmed:meshHeading | pubmed-meshheading:12198616... | lld:pubmed |
| pubmed-article:12198616 | pubmed:meshHeading | pubmed-meshheading:12198616... | lld:pubmed |
| pubmed-article:12198616 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12198616 | pubmed:articleTitle | Functional properties of the T cell receptor repertoire in responding to the protective domain of heat-shock protein 60 from Histoplasma capsulatum. | lld:pubmed |
| pubmed-article:12198616 | pubmed:affiliation | Veterans Affairs Hospital and Department of Medicine, Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0560, USA. george.deepe@uc.edu | lld:pubmed |
| pubmed-article:12198616 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12198616 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12198616 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12198616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12198616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12198616 | lld:pubmed |
