Linked Life Data

12183563

Source:http://linkedlifedata.com/resource/pubmed/id/12183563

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:12183563rdf:typepubmed:Citationlld:pubmed
pubmed-article:12183563lifeskim:mentionsumls-concept:C0008148lld:lifeskim
pubmed-article:12183563lifeskim:mentionsumls-concept:C0026724lld:lifeskim
pubmed-article:12183563lifeskim:mentionsumls-concept:C0559522lld:lifeskim
pubmed-article:12183563lifeskim:mentionsumls-concept:C1522642lld:lifeskim
pubmed-article:12183563lifeskim:mentionsumls-concept:C1545588lld:lifeskim
pubmed-article:12183563lifeskim:mentionsumls-concept:C0729552lld:lifeskim
pubmed-article:12183563lifeskim:mentionsumls-concept:C0392756lld:lifeskim
pubmed-article:12183563lifeskim:mentionsumls-concept:C0599896lld:lifeskim
pubmed-article:12183563lifeskim:mentionsumls-concept:C0870432lld:lifeskim
pubmed-article:12183563lifeskim:mentionsumls-concept:C1705417lld:lifeskim
pubmed-article:12183563lifeskim:mentionsumls-concept:C1555465lld:lifeskim
pubmed-article:12183563lifeskim:mentionsumls-concept:C1999230lld:lifeskim
pubmed-article:12183563pubmed:issue9lld:pubmed
pubmed-article:12183563pubmed:dateCreated2002-8-16lld:pubmed
pubmed-article:12183563pubmed:abstractTextA T helper type 1 (Th1) response is essential for resolving genital infections with the mouse pneumonitis biovar of Chlamydia trachomatis (MoPn). However, T-cell-dependent anti-chlamydial antibody is produced and may also contribute to protective immunity. We produced a MoPn-specific CD4 Th2 clone (Th2-MoPn) to study the role of a Th2 response during infection. We found that Th2-MoPn was unable to eradicate chlamydiae from the genital tract (GT) when it was transferred into MoPn-infected nude mice. Mice that received Th2-MoPn produced greater titers of MoPn-specific serum immunoglobulin G (IgG) antibody than mice that received a MoPn-specific Th1 clone (Th1-MoPn) (log(10) titers, 1.89 +/- 0.84 and 0.58 +/- 0.76 [mean +/- standard deviation], respectively [P < 0.01]). Also, the IgG isotypes were different for the two groups; whereas IgG1 was associated with Th2-MoPn, IgG2a was associated with Th1-MoPn. Also, infected nude mice that received Th2-MoPn produced higher levels of IgA in vaginal secretions. Although clone Th2-MoPn was detected in the GT, it was less efficient at migrating (112 +/- 35.6 labeled Th2 clone cells/10(5) GT cells) than Th1-MoPn (505 +/- 51.6 Th1 clone cells/10(5) GT cells) (P < 0.001, as determined by a t test). This may have been due to reduced expression of alpha4beta7 and P-selectin ligand 1 on Th2-MoPn. However, Th2-MoPn cells were retained in the GT during chronic infection and comprised 10 to 15% of the total GT cells 80 days after transfer. The data show that the MoPn-specific Th2 cells are important for serum and vaginal antibody production and may accumulate in the GT during chronic infection.lld:pubmed
pubmed-article:12183563pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:languageenglld:pubmed
pubmed-article:12183563pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:citationSubsetIMlld:pubmed
pubmed-article:12183563pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12183563pubmed:statusMEDLINElld:pubmed
pubmed-article:12183563pubmed:monthSeplld:pubmed
pubmed-article:12183563pubmed:issn0019-9567lld:pubmed
pubmed-article:12183563pubmed:authorpubmed-author:KellyKathleen...lld:pubmed
pubmed-article:12183563pubmed:authorpubmed-author:RankRoger GRGlld:pubmed
pubmed-article:12183563pubmed:authorpubmed-author:HawkinsRaymon...lld:pubmed
pubmed-article:12183563pubmed:issnTypePrintlld:pubmed
pubmed-article:12183563pubmed:volume70lld:pubmed
pubmed-article:12183563pubmed:ownerNLMlld:pubmed
pubmed-article:12183563pubmed:authorsCompleteYlld:pubmed
pubmed-article:12183563pubmed:pagination5132-9lld:pubmed
pubmed-article:12183563pubmed:dateRevised2009-11-18lld:pubmed
pubmed-article:12183563pubmed:meshHeadingpubmed-meshheading:12183563...lld:pubmed
pubmed-article:12183563pubmed:meshHeadingpubmed-meshheading:12183563...lld:pubmed
pubmed-article:12183563pubmed:meshHeadingpubmed-meshheading:12183563...lld:pubmed
pubmed-article:12183563pubmed:meshHeadingpubmed-meshheading:12183563...lld:pubmed
pubmed-article:12183563pubmed:meshHeadingpubmed-meshheading:12183563...lld:pubmed
pubmed-article:12183563pubmed:meshHeadingpubmed-meshheading:12183563...lld:pubmed
pubmed-article:12183563pubmed:meshHeadingpubmed-meshheading:12183563...lld:pubmed
pubmed-article:12183563pubmed:meshHeadingpubmed-meshheading:12183563...lld:pubmed
pubmed-article:12183563pubmed:meshHeadingpubmed-meshheading:12183563...lld:pubmed
pubmed-article:12183563pubmed:meshHeadingpubmed-meshheading:12183563...lld:pubmed
pubmed-article:12183563pubmed:meshHeadingpubmed-meshheading:12183563...lld:pubmed
pubmed-article:12183563pubmed:meshHeadingpubmed-meshheading:12183563...lld:pubmed
pubmed-article:12183563pubmed:meshHeadingpubmed-meshheading:12183563...lld:pubmed
pubmed-article:12183563pubmed:meshHeadingpubmed-meshheading:12183563...lld:pubmed
pubmed-article:12183563pubmed:meshHeadingpubmed-meshheading:12183563...lld:pubmed
pubmed-article:12183563pubmed:meshHeadingpubmed-meshheading:12183563...lld:pubmed
pubmed-article:12183563pubmed:year2002lld:pubmed
More...