| pubmed-article:12168619 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12168619 | lifeskim:mentions | umls-concept:C0012578 | lld:lifeskim |
| pubmed-article:12168619 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:12168619 | lifeskim:mentions | umls-concept:C1705920 | lld:lifeskim |
| pubmed-article:12168619 | lifeskim:mentions | umls-concept:C0220905 | lld:lifeskim |
| pubmed-article:12168619 | lifeskim:mentions | umls-concept:C0679426 | lld:lifeskim |
| pubmed-article:12168619 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:12168619 | pubmed:dateCreated | 2002-8-9 | lld:pubmed |
| pubmed-article:12168619 | pubmed:abstractText | To what extent and in what way do gene promoters and their transacting regulatory proteins coevolve? In this and in earlier publications we show that the Bicoid-dependent promoters of the segmentation genes hunchback and tailless in species of higher Diptera (Drosophila, Musca, Calliphora, and Lucilia) are different with respect to the copy number, spacing, sequence, and orientation of Bicoid binding sites. At the same time there are significant amino acid differences in the Bicoid homeodomain. To test these interspecific differences, we used a series of functional assays, starting with the analysis of Bicoid binding affinities of individual sites, through to transgene rescue experiments, to compare within-species with between-species mixtures of Bicoid homeodomains and hunchback or tailless promoters. We observed that components taken from different species interact with less efficiency compared with those taken from within the same species. Our interpretation is that such interspecific incompatibilities are a consequence of interactive genetic elements coevolving one with another, hence maintaining functional compatibility within each species. At the same time such a process allows differences to accumulate between species regarding the precise molecular basis whereby the common function is effected. | lld:pubmed |
| pubmed-article:12168619 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12168619 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12168619 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12168619 | pubmed:issn | 1520-541X | lld:pubmed |
| pubmed-article:12168619 | pubmed:author | pubmed-author:DoverG AGA | lld:pubmed |
| pubmed-article:12168619 | pubmed:author | pubmed-author:ShawP JPJ | lld:pubmed |
| pubmed-article:12168619 | pubmed:author | pubmed-author:McGregorA PAP | lld:pubmed |
| pubmed-article:12168619 | pubmed:author | pubmed-author:WrattenN SNS | lld:pubmed |
| pubmed-article:12168619 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12168619 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:12168619 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12168619 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12168619 | pubmed:pagination | 265-77 | lld:pubmed |
| pubmed-article:12168619 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:12168619 | pubmed:articleTitle | Coevolution in bicoid-dependent promoters and the inception of regulatory incompatibilities among species of higher Diptera. | lld:pubmed |
| pubmed-article:12168619 | pubmed:affiliation | Department of Genetics, University of Leicester, UK. sjb28@le.ac.uk | lld:pubmed |
| pubmed-article:12168619 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12168619 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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