Uncovering the cause of a suspected myopathy may be challenging. However, a careful approach starts with utilizing the wealth of available information regarding the clinical and laboratory features of myopathy. Electrodiagnostic testing is then obtained (in most cases). Recognition of the pattern of EMG findings in light of the clinical and laboratory features should narrow the differential diagnosis and dictate the next steps in the evaluation. Histopathologic or molecular studies, or both may follow. Ultimately, this approach usually allows the clinician to make the correct diagnosis.
Departments of Neurology and Pathology (Neuropathology), University of Pittsburgh, School of Medicine, 200 Lothrop Street, PUH F-878, Pittsburgh, PA 15213, USA. lacomis@np.awing.upmc.edu
