| pubmed-article:12133944 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12133944 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:12133944 | lifeskim:mentions | umls-concept:C0221908 | lld:lifeskim |
| pubmed-article:12133944 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:12133944 | lifeskim:mentions | umls-concept:C0524637 | lld:lifeskim |
| pubmed-article:12133944 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:12133944 | lifeskim:mentions | umls-concept:C0024518 | lld:lifeskim |
| pubmed-article:12133944 | lifeskim:mentions | umls-concept:C0425152 | lld:lifeskim |
| pubmed-article:12133944 | lifeskim:mentions | umls-concept:C1823153 | lld:lifeskim |
| pubmed-article:12133944 | lifeskim:mentions | umls-concept:C1524075 | lld:lifeskim |
| pubmed-article:12133944 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:12133944 | lifeskim:mentions | umls-concept:C0037791 | lld:lifeskim |
| pubmed-article:12133944 | lifeskim:mentions | umls-concept:C1705241 | lld:lifeskim |
| pubmed-article:12133944 | lifeskim:mentions | umls-concept:C0439097 | lld:lifeskim |
| pubmed-article:12133944 | lifeskim:mentions | umls-concept:C2349976 | lld:lifeskim |
| pubmed-article:12133944 | lifeskim:mentions | umls-concept:C1552644 | lld:lifeskim |
| pubmed-article:12133944 | lifeskim:mentions | umls-concept:C1547348 | lld:lifeskim |
| pubmed-article:12133944 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12133944 | pubmed:dateCreated | 2002-7-22 | lld:pubmed |
| pubmed-article:12133944 | pubmed:abstractText | Human gamma delta T cells with the TCR variable region V(delta)1 occur mainly in epithelia and respond to stress-induced expression of the MHC class I-related chains A and B, which have no function in Ag presentation. MIC function as ligands for NKG2D-DAP10, an activating receptor complex that triggers NK cells, costimulates CD8 alpha beta and V(gamma)9V(delta)2 gamma delta T cells, and is required for stimulation of V(delta)1 gamma delta T cells. It is unresolved, however, whether triggering of V(delta)1 gamma delta TCRs is also mediated by MIC or by unidentified cell surface components. Soluble MICA tetramers were used as a binding reagent to demonstrate specific interactions with various V(delta)1 gamma delta TCRs expressed on transfectants of a T cell line selected for lack of NKG2D. Tetramer binding was restricted to TCRs derived from responder T cell clones classified as reactive against a broad range of MIC-expressing target cells and was abrogated when TCRs were composed of mismatched gamma- and delta-chains. These results and the inability of V(delta)1 gamma delta T cells to respond to target cells expressing the ULBP/N2DL ligands of NKG2D, which are highly divergent from MIC, indicate that MIC delivers both the TCR-dependent signal 1 and the NKG2D-dependent costimulatory signal 2. This dual function may serve to prevent erroneous gamma delta T cell activation by cross-reactive cell surface determinants. | lld:pubmed |
| pubmed-article:12133944 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12133944 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12133944 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12133944 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12133944 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:12133944 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12133944 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12133944 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12133944 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12133944 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12133944 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12133944 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12133944 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12133944 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12133944 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12133944 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:12133944 | pubmed:author | pubmed-author:GrohVeronikaV | lld:pubmed |
| pubmed-article:12133944 | pubmed:author | pubmed-author:SpiesThomasT | lld:pubmed |
| pubmed-article:12133944 | pubmed:author | pubmed-author:WuJenniferJ | lld:pubmed |
| pubmed-article:12133944 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12133944 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:12133944 | pubmed:volume | 169 | lld:pubmed |
| pubmed-article:12133944 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12133944 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12133944 | pubmed:pagination | 1236-40 | lld:pubmed |
| pubmed-article:12133944 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:12133944 | pubmed:meshHeading | pubmed-meshheading:12133944... | lld:pubmed |
| pubmed-article:12133944 | pubmed:meshHeading | pubmed-meshheading:12133944... | lld:pubmed |
| pubmed-article:12133944 | pubmed:meshHeading | pubmed-meshheading:12133944... | lld:pubmed |
| pubmed-article:12133944 | pubmed:meshHeading | pubmed-meshheading:12133944... | lld:pubmed |
| pubmed-article:12133944 | pubmed:meshHeading | pubmed-meshheading:12133944... | lld:pubmed |
| pubmed-article:12133944 | pubmed:meshHeading | pubmed-meshheading:12133944... | lld:pubmed |
| pubmed-article:12133944 | pubmed:meshHeading | pubmed-meshheading:12133944... | lld:pubmed |
| pubmed-article:12133944 | pubmed:meshHeading | pubmed-meshheading:12133944... | lld:pubmed |
| pubmed-article:12133944 | pubmed:meshHeading | pubmed-meshheading:12133944... | lld:pubmed |
| pubmed-article:12133944 | pubmed:meshHeading | pubmed-meshheading:12133944... | lld:pubmed |
| pubmed-article:12133944 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12133944 | pubmed:articleTitle | T cell antigen receptor engagement and specificity in the recognition of stress-inducible MHC class I-related chains by human epithelial gamma delta T cells. | lld:pubmed |
| pubmed-article:12133944 | pubmed:affiliation | Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. | lld:pubmed |
| pubmed-article:12133944 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12133944 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12133944 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12133944 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12133944 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12133944 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12133944 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12133944 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12133944 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12133944 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12133944 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12133944 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12133944 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12133944 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12133944 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12133944 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12133944 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12133944 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12133944 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12133944 | lld:pubmed |
