| pubmed-article:12132656 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12132656 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:12132656 | lifeskim:mentions | umls-concept:C0521425 | lld:lifeskim |
| pubmed-article:12132656 | lifeskim:mentions | umls-concept:C0015914 | lld:lifeskim |
| pubmed-article:12132656 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:12132656 | lifeskim:mentions | umls-concept:C1424222 | lld:lifeskim |
| pubmed-article:12132656 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:12132656 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:12132656 | pubmed:dateCreated | 2002-7-22 | lld:pubmed |
| pubmed-article:12132656 | pubmed:abstractText | DJ-1 was first identified as an activated ras-dependent oncogene product and was later also found to be an infertility-related protein affected by sperm toxicants such as ornidazole (OR) and epichlorohydrin. These findings suggest that DJ-1 has functions in both somatic cells and sperm. In this study, to determine the relationship between DJ-1 and an endocrine disrupter and to determine the functions of DJ-1 in sperm, in vitro fertilization experiments were carried out using eggs and sperm extracted from mice that had or had not been treated with OR. We found that the amount of DJ-1 in sperm and the efficiency of fertilization decreased with the increasing dose of OR to which the mice were exposed. The addition of an anti-mouse DJ-1 serum to sperm solution before the in vitro fertilization reaction with eggs resulted in a decrease in the efficiency of fertilization to about one-third of that when pre-immune serum was added to sperm solution, indicating that DJ-1 participates in the fertilization. | lld:pubmed |
| pubmed-article:12132656 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12132656 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12132656 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12132656 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12132656 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12132656 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12132656 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12132656 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12132656 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12132656 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12132656 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12132656 | pubmed:issn | 0918-6158 | lld:pubmed |
| pubmed-article:12132656 | pubmed:author | pubmed-author:OkadaMasahiko... | lld:pubmed |
| pubmed-article:12132656 | pubmed:author | pubmed-author:ArigaHiroyosh... | lld:pubmed |
| pubmed-article:12132656 | pubmed:author | pubmed-author:MatsumotoKen-... | lld:pubmed |
| pubmed-article:12132656 | pubmed:author | pubmed-author:NikiTakeshiT | lld:pubmed |
| pubmed-article:12132656 | pubmed:author | pubmed-author:TairaTakahiro... | lld:pubmed |
| pubmed-article:12132656 | pubmed:author | pubmed-author:Iguchi-ArigaS... | lld:pubmed |
| pubmed-article:12132656 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12132656 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:12132656 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12132656 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12132656 | pubmed:pagination | 853-6 | lld:pubmed |
| pubmed-article:12132656 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:12132656 | pubmed:meshHeading | pubmed-meshheading:12132656... | lld:pubmed |
| pubmed-article:12132656 | pubmed:meshHeading | pubmed-meshheading:12132656... | lld:pubmed |
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| pubmed-article:12132656 | pubmed:meshHeading | pubmed-meshheading:12132656... | lld:pubmed |
| pubmed-article:12132656 | pubmed:meshHeading | pubmed-meshheading:12132656... | lld:pubmed |
| pubmed-article:12132656 | pubmed:meshHeading | pubmed-meshheading:12132656... | lld:pubmed |
| pubmed-article:12132656 | pubmed:meshHeading | pubmed-meshheading:12132656... | lld:pubmed |
| pubmed-article:12132656 | pubmed:meshHeading | pubmed-meshheading:12132656... | lld:pubmed |
| pubmed-article:12132656 | pubmed:meshHeading | pubmed-meshheading:12132656... | lld:pubmed |
| pubmed-article:12132656 | pubmed:meshHeading | pubmed-meshheading:12132656... | lld:pubmed |
| pubmed-article:12132656 | pubmed:meshHeading | pubmed-meshheading:12132656... | lld:pubmed |
| pubmed-article:12132656 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12132656 | pubmed:articleTitle | DJ-1, a target protein for an endocrine disrupter, participates in the fertilization in mice. | lld:pubmed |
| pubmed-article:12132656 | pubmed:affiliation | Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan. | lld:pubmed |
| pubmed-article:12132656 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12132656 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:57320 | entrezgene:pubmed | pubmed-article:12132656 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12132656 | lld:entrezgene |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12132656 | lld:pubmed |
