| pubmed-article:12124436 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12124436 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:12124436 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:12124436 | lifeskim:mentions | umls-concept:C0567416 | lld:lifeskim |
| pubmed-article:12124436 | lifeskim:mentions | umls-concept:C1512035 | lld:lifeskim |
| pubmed-article:12124436 | lifeskim:mentions | umls-concept:C0025462 | lld:lifeskim |
| pubmed-article:12124436 | lifeskim:mentions | umls-concept:C1704448 | lld:lifeskim |
| pubmed-article:12124436 | lifeskim:mentions | umls-concept:C0671702 | lld:lifeskim |
| pubmed-article:12124436 | lifeskim:mentions | umls-concept:C0038952 | lld:lifeskim |
| pubmed-article:12124436 | lifeskim:mentions | umls-concept:C1335280 | lld:lifeskim |
| pubmed-article:12124436 | lifeskim:mentions | umls-concept:C1706044 | lld:lifeskim |
| pubmed-article:12124436 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:12124436 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:12124436 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:12124436 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:12124436 | pubmed:dateCreated | 2002-7-18 | lld:pubmed |
| pubmed-article:12124436 | pubmed:abstractText | To examine the roles of Shp-2, a cytoplasmic tyrosine phosphatase, in neuronal survival, we generated and used recombinant adenoviruses expressing wild type and phosphatase-inactive (C/S), phosphatase domain-deficient (delta P) and constitutively active (D61A and E76A) mutants of Shp-2. We found that wild-type Shp-2 enhanced brain-derived neurotrophic factor (BDNF)-promoted survival of cultured ventral mesencephalic dopaminergic neurons. In contrast, the C/S and delta P mutants of Shp-2 did not affect survival. In addition, the constitutively active D61A and E76A mutants mimicked BDNF and promoted survival. Furthermore, to examine the effects of BIT/SHPS-1, a substrate of Shp-2, on the BDNF-promoted survival, we generated adenovirus vectors expressing wild-type BIT/SHPS-1 and its 4F mutant in which all tyrosine residues in the cytoplasmic domain of BIT/SHPS-1 were replaced with phenylalanine. We found that BDNF-promoted survival of cultured mesencephalic dopaminergic neurons was enhanced by expression of the 4F mutant but not of wild-type BIT/SHPS-1. In addition, we found that co-expression of wild-type BIT/SHPS-1 with Shp-2 significantly enhanced the survival-promoting effect of BDNF on cultured mesencephalic dopaminergic neurons. These results indicated that Shp-2 positively regulates the survival-promoting effect of BDNF on cultured ventral mesencephalic dopaminergic neurons. Dephosphorylation of BIT/SHPS-1 by Shp-2 may participate in BDNF-stimulated survival signaling. | lld:pubmed |
| pubmed-article:12124436 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12124436 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12124436 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12124436 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12124436 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12124436 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12124436 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12124436 | pubmed:issn | 0022-3042 | lld:pubmed |
| pubmed-article:12124436 | pubmed:author | pubmed-author:YamadaMasashi... | lld:pubmed |
| pubmed-article:12124436 | pubmed:author | pubmed-author:HatanakaHiros... | lld:pubmed |
| pubmed-article:12124436 | pubmed:author | pubmed-author:ArakiToshiyuk... | lld:pubmed |
| pubmed-article:12124436 | pubmed:author | pubmed-author:KoshimizuHisa... | lld:pubmed |
| pubmed-article:12124436 | pubmed:author | pubmed-author:TakaiSatomiS | lld:pubmed |
| pubmed-article:12124436 | pubmed:author | pubmed-author:NawaHiroyukiH | lld:pubmed |
| pubmed-article:12124436 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12124436 | pubmed:volume | 82 | lld:pubmed |
| pubmed-article:12124436 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12124436 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12124436 | pubmed:pagination | 353-64 | lld:pubmed |
| pubmed-article:12124436 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:12124436 | pubmed:meshHeading | pubmed-meshheading:12124436... | lld:pubmed |
| pubmed-article:12124436 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12124436 | pubmed:articleTitle | Shp-2 positively regulates brain-derived neurotrophic factor-promoted survival of cultured ventral mesencephalic dopaminergic neurons through a brain immunoglobulin-like molecule with tyrosine-based activation motifs/Shp substrate-1. | lld:pubmed |
| pubmed-article:12124436 | pubmed:affiliation | Division of Protein Biosynthesis, Institute for Protein Research, Osaka University, Suita, Japan. | lld:pubmed |
| pubmed-article:12124436 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12124436 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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