| pubmed-article:12121917 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12121917 | lifeskim:mentions | umls-concept:C0020235 | lld:lifeskim |
| pubmed-article:12121917 | lifeskim:mentions | umls-concept:C1825576 | lld:lifeskim |
| pubmed-article:12121917 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:12121917 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:12121917 | pubmed:dateCreated | 2002-7-17 | lld:pubmed |
| pubmed-article:12121917 | pubmed:abstractText | Members of a family of N-arylsulfonyl hydrazones have been identified as novel inhibitors of IMP-1, a metallo-beta-lactamase of increasing prevalence. Structure-activity relationship studies have indicated a requirement for bulky aromatic substituents on each side of the sulfonyl hydrazone backbone for these compounds to serve as efficient inhibitors of IMP-1. Molecular modeling has provided insight into the structural basis for the anti-metallo-beta-lactamase activity exhibited by this class of compounds. | lld:pubmed |
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| pubmed-article:12121917 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12121917 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12121917 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12121917 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12121917 | pubmed:issn | 0066-4804 | lld:pubmed |
| pubmed-article:12121917 | pubmed:author | pubmed-author:ClarkeAnthony... | lld:pubmed |
| pubmed-article:12121917 | pubmed:author | pubmed-author:DmitrienkoGar... | lld:pubmed |
| pubmed-article:12121917 | pubmed:author | pubmed-author:SiemannStefan... | lld:pubmed |
| pubmed-article:12121917 | pubmed:author | pubmed-author:ViswanathaTha... | lld:pubmed |
| pubmed-article:12121917 | pubmed:author | pubmed-author:EvanoffDarryl... | lld:pubmed |
| pubmed-article:12121917 | pubmed:author | pubmed-author:MarroneLauraL | lld:pubmed |
| pubmed-article:12121917 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12121917 | pubmed:volume | 46 | lld:pubmed |
| pubmed-article:12121917 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12121917 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12121917 | pubmed:pagination | 2450-7 | lld:pubmed |
| pubmed-article:12121917 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:12121917 | pubmed:meshHeading | pubmed-meshheading:12121917... | lld:pubmed |
| pubmed-article:12121917 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12121917 | pubmed:articleTitle | N-arylsulfonyl hydrazones as inhibitors of IMP-1 metallo-beta-lactamase. | lld:pubmed |
| pubmed-article:12121917 | pubmed:affiliation | Department of Chemistry, University of Waterloo, 200 University Avenue W., Waterloo, Ontario N2L 3G1, Canada. | lld:pubmed |
| pubmed-article:12121917 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12121917 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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