| pubmed-article:12113834 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12113834 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:12113834 | lifeskim:mentions | umls-concept:C0040676 | lld:lifeskim |
| pubmed-article:12113834 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:12113834 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:12113834 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:12113834 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:12113834 | lifeskim:mentions | umls-concept:C1554184 | lld:lifeskim |
| pubmed-article:12113834 | lifeskim:mentions | umls-concept:C0205549 | lld:lifeskim |
| pubmed-article:12113834 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:12113834 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:12113834 | pubmed:dateCreated | 2002-7-12 | lld:pubmed |
| pubmed-article:12113834 | pubmed:abstractText | We have prepared a series of potent, dual inhibitors of the prenyl transferases farnesyl protein transferase (FPTase) and geranyl-geranyl protein transferase I (GGPTase). The compounds were shown to possess potent activity against both enzymes in cell culture. Mechanistic analysis has shown that the compounds are CAAX competitive for FPTase inhibition but geranyl-geranyl pyrophosphate (GGPP) competitive for GGPTase inhibiton. | lld:pubmed |
| pubmed-article:12113834 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12113834 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12113834 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12113834 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12113834 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12113834 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12113834 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12113834 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12113834 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12113834 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12113834 | pubmed:issn | 0960-894X | lld:pubmed |
| pubmed-article:12113834 | pubmed:author | pubmed-author:HartmanGeorge... | lld:pubmed |
| pubmed-article:12113834 | pubmed:author | pubmed-author:FernandesChri... | lld:pubmed |
| pubmed-article:12113834 | pubmed:author | pubmed-author:DavideJoseph... | lld:pubmed |
| pubmed-article:12113834 | pubmed:author | pubmed-author:Ellis-Hutchin... | lld:pubmed |
| pubmed-article:12113834 | pubmed:author | pubmed-author:RobinsonRonal... | lld:pubmed |
| pubmed-article:12113834 | pubmed:author | pubmed-author:LobellRobert... | lld:pubmed |
| pubmed-article:12113834 | pubmed:author | pubmed-author:HuberHans EHE | lld:pubmed |
| pubmed-article:12113834 | pubmed:author | pubmed-author:BuserCarolyn... | lld:pubmed |
| pubmed-article:12113834 | pubmed:author | pubmed-author:GibbsJackson... | lld:pubmed |
| pubmed-article:12113834 | pubmed:author | pubmed-author:GrahamSamuel... | lld:pubmed |
| pubmed-article:12113834 | pubmed:author | pubmed-author:TuckerThomas... | lld:pubmed |
| pubmed-article:12113834 | pubmed:author | pubmed-author:AbramsMarc... | lld:pubmed |
| pubmed-article:12113834 | pubmed:author | pubmed-author:LiuDongmingD | lld:pubmed |
| pubmed-article:12113834 | pubmed:author | pubmed-author:LummaWilliam... | lld:pubmed |
| pubmed-article:12113834 | pubmed:author | pubmed-author:SiskoJohn TJT | lld:pubmed |
| pubmed-article:12113834 | pubmed:author | pubmed-author:SmithAnthony... | lld:pubmed |
| pubmed-article:12113834 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12113834 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:12113834 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:12113834 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12113834 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12113834 | pubmed:pagination | 2027-30 | lld:pubmed |
| pubmed-article:12113834 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12113834 | pubmed:meshHeading | pubmed-meshheading:12113834... | lld:pubmed |
| pubmed-article:12113834 | pubmed:meshHeading | pubmed-meshheading:12113834... | lld:pubmed |
| pubmed-article:12113834 | pubmed:meshHeading | pubmed-meshheading:12113834... | lld:pubmed |
| pubmed-article:12113834 | pubmed:meshHeading | pubmed-meshheading:12113834... | lld:pubmed |
| pubmed-article:12113834 | pubmed:meshHeading | pubmed-meshheading:12113834... | lld:pubmed |
| pubmed-article:12113834 | pubmed:meshHeading | pubmed-meshheading:12113834... | lld:pubmed |
| pubmed-article:12113834 | pubmed:meshHeading | pubmed-meshheading:12113834... | lld:pubmed |
| pubmed-article:12113834 | pubmed:meshHeading | pubmed-meshheading:12113834... | lld:pubmed |
| pubmed-article:12113834 | pubmed:meshHeading | pubmed-meshheading:12113834... | lld:pubmed |
| pubmed-article:12113834 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12113834 | pubmed:articleTitle | The synthesis and biological evaluation of a series of potent dual inhibitors of farnesyl and geranyl-Geranyl protein transferases. | lld:pubmed |
| pubmed-article:12113834 | pubmed:affiliation | Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 4, Sumneytown Pike, West Point, PA 19486, USA. tom_tucker@merck.com | lld:pubmed |
| pubmed-article:12113834 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:12113834 | lld:chembl |
