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pubmed-article:12113075pubmed:abstractTextIdentification of tumor-specific target antigens has been a major hurdle for the treatment of malignant disease by vaccination or immunotherapy. A second challenge has been the induction of therapeutically effective immune responses to these 'self' antigens. The recent recognition of dendritic cells as powerful antigen-presenting cells capable of inducing primary T-cell responses in vitro and in vivo--in combination with identification of tumor-specific antigens--has generated widespread interest in dendritic cell-based immunotherapy against a wide variety of tumors. In this review, a series of recently identified novel ovarian tumor antigens is discussed, and the potential for therapeutic dendritic cell vaccination targeted against these antigens is assessed.lld:pubmed
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pubmed-article:12113075pubmed:authorpubmed-author:CannonMartin...lld:pubmed
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pubmed-article:12113075pubmed:dateRevised2007-11-15lld:pubmed
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pubmed-article:12113075pubmed:year2002lld:pubmed
pubmed-article:12113075pubmed:articleTitleNovel target antigens for dendritic cell-based immunotherapy against ovarian cancer.lld:pubmed
pubmed-article:12113075pubmed:affiliationDepartment of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, AR 72205, USA. cannonmartin@uams.edulld:pubmed
pubmed-article:12113075pubmed:publicationTypeJournal Articlelld:pubmed
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