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pubmed-article:12107595pubmed:abstractTextMurid rodents show much less variation in isochore base composition than do most other mammals, a difference which has been referred to as the murid shift. We have investigated the murid shift by asking (1) whether the murid shift is ongoing and (2) whether there is any evidence of selection or biased gene conversion affecting base composition in the present-day mouse genome. By estimating the ancestral base composition of protein-coding genes in murids we can confirm that the murid shift is ongoing. Tests using nongenic polymorphism data fail to reject the hypothesis that base composition is due to mutation bias alone. However, the patterns of compositional change suggested by the polymorphism and divergence data differ, suggesting the possibility of two murid shifts.lld:pubmed
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pubmed-article:12107595pubmed:issn0022-2844lld:pubmed
pubmed-article:12107595pubmed:authorpubmed-author:SmithNick G...lld:pubmed
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pubmed-article:12107595pubmed:pagination197-201lld:pubmed
pubmed-article:12107595pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:12107595pubmed:year2002lld:pubmed
pubmed-article:12107595pubmed:articleTitleThe compositional evolution of the murid genome.lld:pubmed
pubmed-article:12107595pubmed:affiliationDepartment of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvägen 18D, SE-752 36 Uppsala, Sweden. nick.smith@ebc.uu.selld:pubmed
pubmed-article:12107595pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12107595pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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