| pubmed-article:12107181 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12107181 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:12107181 | lifeskim:mentions | umls-concept:C0001455 | lld:lifeskim |
| pubmed-article:12107181 | lifeskim:mentions | umls-concept:C0056695 | lld:lifeskim |
| pubmed-article:12107181 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:12107181 | lifeskim:mentions | umls-concept:C1413688 | lld:lifeskim |
| pubmed-article:12107181 | lifeskim:mentions | umls-concept:C1415629 | lld:lifeskim |
| pubmed-article:12107181 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:12107181 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:12107181 | lifeskim:mentions | umls-concept:C0205195 | lld:lifeskim |
| pubmed-article:12107181 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:12107181 | pubmed:issue | 41 | lld:pubmed |
| pubmed-article:12107181 | pubmed:dateCreated | 2002-10-7 | lld:pubmed |
| pubmed-article:12107181 | pubmed:abstractText | Liver carnitine palmitoyltransferase I catalyzes the transfer of long-chain fatty acids into mitochondria. L-CPT I is considered the rate-controlling enzyme in fatty acid oxidation. Expression of the L-CPT I gene is induced by starvation in response to glucagon secretion from the pancreas, an effect mediated by cAMP. Here, the molecular mechanisms underlying the induction of L-CPT I gene expression by cAMP were characterized. We demonstrate that the cAMP response unit of the L-CPT I gene is composed of a cAMP-response element motif and a DR1 sequence located 3 kb upstream of the transcription start site. Our data strongly suggest that the coactivator PGC-1 is involved in the regulation of this gene expression by cAMP in combination with HNF4 alpha and cAMP-response element-binding protein (CREB). Indeed, (i) cotransfection of CREB or HNF4 alpha dominant negative mutants completely abolishes the effect of cAMP on the L-CPT I promoter, and (ii) the cAMP-responsive unit binds HNF4 alpha and CREB through the DR1 and the cAMP-response element sequences, respectively. Moreover, cotransfection of PGC-1 strongly activates the L-CPT I promoter through HNF4 alpha bound at the DR1 element. Finally, we show that the transcriptional induction of the PGC-1 gene by glucagon through cAMP in hepatocytes precedes that of L-CPT-1. In addition to the key role that PGC-1 plays in glucose homeostasis, it may also be critical for lipid homeostasis. Taken together these observations suggest that PGC-1 acts to coordinate the process of metabolic adaptation in the liver. | lld:pubmed |
| pubmed-article:12107181 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12107181 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12107181 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12107181 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12107181 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12107181 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12107181 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12107181 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12107181 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12107181 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12107181 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12107181 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12107181 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12107181 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12107181 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12107181 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12107181 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12107181 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12107181 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:12107181 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:12107181 | pubmed:author | pubmed-author:GirardJeanJ | lld:pubmed |
| pubmed-article:12107181 | pubmed:author | pubmed-author:GonzalezFrank... | lld:pubmed |
| pubmed-article:12107181 | pubmed:author | pubmed-author:LouetJean-Fra... | lld:pubmed |
| pubmed-article:12107181 | pubmed:author | pubmed-author:HayhurstGraha... | lld:pubmed |
| pubmed-article:12107181 | pubmed:author | pubmed-author:DecauxJean-Fr... | lld:pubmed |
| pubmed-article:12107181 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12107181 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:12107181 | pubmed:volume | 277 | lld:pubmed |
| pubmed-article:12107181 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12107181 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12107181 | pubmed:pagination | 37991-8000 | lld:pubmed |
| pubmed-article:12107181 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:12107181 | pubmed:meshHeading | pubmed-meshheading:12107181... | lld:pubmed |
| pubmed-article:12107181 | pubmed:meshHeading | pubmed-meshheading:12107181... | lld:pubmed |
| pubmed-article:12107181 | pubmed:meshHeading | pubmed-meshheading:12107181... | lld:pubmed |
| pubmed-article:12107181 | pubmed:meshHeading | pubmed-meshheading:12107181... | lld:pubmed |
| pubmed-article:12107181 | pubmed:meshHeading | pubmed-meshheading:12107181... | lld:pubmed |
| pubmed-article:12107181 | pubmed:meshHeading | pubmed-meshheading:12107181... | lld:pubmed |
| pubmed-article:12107181 | pubmed:meshHeading | pubmed-meshheading:12107181... | lld:pubmed |
| pubmed-article:12107181 | pubmed:meshHeading | pubmed-meshheading:12107181... | lld:pubmed |
| pubmed-article:12107181 | pubmed:meshHeading | pubmed-meshheading:12107181... | lld:pubmed |
| pubmed-article:12107181 | pubmed:meshHeading | pubmed-meshheading:12107181... | lld:pubmed |
| pubmed-article:12107181 | pubmed:meshHeading | pubmed-meshheading:12107181... | lld:pubmed |
| pubmed-article:12107181 | pubmed:meshHeading | pubmed-meshheading:12107181... | lld:pubmed |
| pubmed-article:12107181 | pubmed:meshHeading | pubmed-meshheading:12107181... | lld:pubmed |
| pubmed-article:12107181 | pubmed:meshHeading | pubmed-meshheading:12107181... | lld:pubmed |
| pubmed-article:12107181 | pubmed:meshHeading | pubmed-meshheading:12107181... | lld:pubmed |
| pubmed-article:12107181 | pubmed:meshHeading | pubmed-meshheading:12107181... | lld:pubmed |
| pubmed-article:12107181 | pubmed:meshHeading | pubmed-meshheading:12107181... | lld:pubmed |
| pubmed-article:12107181 | pubmed:meshHeading | pubmed-meshheading:12107181... | lld:pubmed |
| pubmed-article:12107181 | pubmed:meshHeading | pubmed-meshheading:12107181... | lld:pubmed |
| pubmed-article:12107181 | pubmed:meshHeading | pubmed-meshheading:12107181... | lld:pubmed |
| pubmed-article:12107181 | pubmed:meshHeading | pubmed-meshheading:12107181... | lld:pubmed |
| pubmed-article:12107181 | pubmed:meshHeading | pubmed-meshheading:12107181... | lld:pubmed |
| pubmed-article:12107181 | pubmed:meshHeading | pubmed-meshheading:12107181... | lld:pubmed |
| pubmed-article:12107181 | pubmed:meshHeading | pubmed-meshheading:12107181... | lld:pubmed |
| pubmed-article:12107181 | pubmed:meshHeading | pubmed-meshheading:12107181... | lld:pubmed |
| pubmed-article:12107181 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12107181 | pubmed:articleTitle | The coactivator PGC-1 is involved in the regulation of the liver carnitine palmitoyltransferase I gene expression by cAMP in combination with HNF4 alpha and cAMP-response element-binding protein (CREB). | lld:pubmed |
| pubmed-article:12107181 | pubmed:affiliation | Institut Cochin, Département d'Endocrinologie, 24 rue du Faubourg Saint Jacques, 75014 Paris, France. | lld:pubmed |
| pubmed-article:12107181 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12107181 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:12894 | entrezgene:pubmed | pubmed-article:12107181 | lld:entrezgene |
| entrez-gene:15378 | entrezgene:pubmed | pubmed-article:12107181 | lld:entrezgene |
| entrez-gene:25735 | entrezgene:pubmed | pubmed-article:12107181 | lld:entrezgene |
| entrez-gene:25757 | entrezgene:pubmed | pubmed-article:12107181 | lld:entrezgene |
| entrez-gene:81646 | entrezgene:pubmed | pubmed-article:12107181 | lld:entrezgene |
| entrez-gene:83516 | entrezgene:pubmed | pubmed-article:12107181 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12107181 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12107181 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12107181 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12107181 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12107181 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12107181 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12107181 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12107181 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12107181 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12107181 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12107181 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12107181 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12107181 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12107181 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12107181 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12107181 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12107181 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12107181 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12107181 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12107181 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12107181 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12107181 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12107181 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12107181 | lld:pubmed |
