| pubmed-article:12098517 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12098517 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:12098517 | lifeskim:mentions | umls-concept:C0031307 | lld:lifeskim |
| pubmed-article:12098517 | lifeskim:mentions | umls-concept:C0038585 | lld:lifeskim |
| pubmed-article:12098517 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:12098517 | lifeskim:mentions | umls-concept:C0231491 | lld:lifeskim |
| pubmed-article:12098517 | lifeskim:mentions | umls-concept:C1513475 | lld:lifeskim |
| pubmed-article:12098517 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:12098517 | pubmed:dateCreated | 2002-7-5 | lld:pubmed |
| pubmed-article:12098517 | pubmed:abstractText | Substance P (SP), a potent modulator of neuroimmunoregulation, exerts its activity by binding to the neurokinin-1 receptor (NK-1R). The SP-NK-1R interaction is important in inflammation and viral infections, including HIV infection of human immune cells. We recently demonstrated that SP modulates HIV replication and that a non-peptide SP antagonist CP-96,345 inhibits HIV replication in human monocyte-derived macrophages (MDM) by affecting the SP-NK-1R interaction. In order to examine the effect of the SP antagonist on SP mRNA expression, MDM was incubated with or without CP-96,345 in the presence or absence of HIV infection. SP mRNA expression in these cells was then determined by real-time PCR technology. The effect of CP-96,345 on chemokine gene expression was also investigated by using a cDNA array assay. CP-96,345 down-regulated SP mRNA expression and antagonized exogenous SP-enhanced SP expression at the mRNA level, suggesting that SP autocrine regulation was interrupted by CP-96,345. CP-96,345 inhibited HIV replication in MDM, associated with down-regulated SP mRNA expression in comparison to HIV infection controls. In parallel with down-regulated SP and CCR5 mRNA expression, cDNA array assays indicated that CP-96,345 treatment also inhibited IL-8 gene expression, while enhancing expression of fractalkine and monocyte chemotactic protein-3 (MCP-3). Since SP plays an important role in inflammation and viral infections, these studies may have potential applications for therapeutic intervention of inflammation and viral infection of immune cells. | lld:pubmed |
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| pubmed-article:12098517 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12098517 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12098517 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12098517 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12098517 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12098517 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12098517 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12098517 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12098517 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12098517 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12098517 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12098517 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12098517 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12098517 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12098517 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12098517 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12098517 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12098517 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12098517 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12098517 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12098517 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12098517 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12098517 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12098517 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12098517 | pubmed:issn | 0165-5728 | lld:pubmed |
| pubmed-article:12098517 | pubmed:author | pubmed-author:WangXuX | lld:pubmed |
| pubmed-article:12098517 | pubmed:author | pubmed-author:DouglasSteven... | lld:pubmed |
| pubmed-article:12098517 | pubmed:author | pubmed-author:HoWen-ZheWZ | lld:pubmed |
| pubmed-article:12098517 | pubmed:author | pubmed-author:LaiJian-PingJ... | lld:pubmed |
| pubmed-article:12098517 | pubmed:author | pubmed-author:ROSSJ KJK | lld:pubmed |
| pubmed-article:12098517 | pubmed:author | pubmed-author:YangJi-HongJH | lld:pubmed |
| pubmed-article:12098517 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12098517 | pubmed:volume | 128 | lld:pubmed |
| pubmed-article:12098517 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12098517 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12098517 | pubmed:pagination | 101-8 | lld:pubmed |
| pubmed-article:12098517 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:12098517 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12098517 | pubmed:articleTitle | A non-peptide substance P antagonist down-regulates SP mRNA expression in human mononuclear phagocytes. | lld:pubmed |
| pubmed-article:12098517 | pubmed:affiliation | Division of Immunologic and Infectious Diseases, Joseph Stokes Jr. Research Institute at the Children's Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA. | lld:pubmed |
| pubmed-article:12098517 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12098517 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| entrez-gene:6354 | entrezgene:pubmed | pubmed-article:12098517 | lld:entrezgene |
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