| pubmed-article:12077266 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12077266 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:12077266 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:12077266 | lifeskim:mentions | umls-concept:C0026926 | lld:lifeskim |
| pubmed-article:12077266 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:12077266 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:12077266 | lifeskim:mentions | umls-concept:C0021747 | lld:lifeskim |
| pubmed-article:12077266 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:12077266 | lifeskim:mentions | umls-concept:C1415900 | lld:lifeskim |
| pubmed-article:12077266 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:12077266 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:12077266 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12077266 | pubmed:dateCreated | 2002-6-21 | lld:pubmed |
| pubmed-article:12077266 | pubmed:abstractText | Type I IFN regulates different aspects of the immune response, inducing a cell-mediated immunity. We have recently shown that the infection of dendritic cells (DC) with Mycobacterium tuberculosis (Mtb) induces IFN-alpha. In this work we have monitored a rapid induction of IFN-beta followed by the delayed production of the IFN-alpha1 and/or -alpha13 subtypes. The Mtb infection rapidly activates the NF-kappaB complex and stimulates the phosphorylation of IFN regulatory factor (IRF)-3, events known to induce IFN-beta expression in viral infection. In turn, the autocrine production of IFN-beta induces the IFN-stimulated genes that contain binding sites for activated STATs in their promoters. Among the IFN-stimulated genes induced in DC through STAT activation are IRF-1 and IRF-7. The expression of IRF-1 appears to be dependent on the sequential activation of NF-kappaB and STAT-1. Once expressed, IRF-1 may further stimulate the transcription of IFN-beta. Induction of IRF-7 is also regulated at the transcriptional level through the binding of phosphorylated STAT-1 and STAT-2, forming the IFN-stimulated gene factor-3 complex. In turn, the IRF-1 and IRF-7 expression appears to be required for the delayed induction of the IFN-alpha1/13 genes. Although correlative, our results strongly support the existence of a cascade of molecular events in Mtb-infected DC. Upon infection, constitutively expressed NF-kappaB and IRF-3 are activated and likely contribute to the rapid IFN-beta expression. In turn, IFN-beta-induced IRF-1 and IRF-7 may cooperate toward induction of IFN-alpha1/13 if infection persists and these factors are activated. | lld:pubmed |
| pubmed-article:12077266 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12077266 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12077266 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:12077266 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12077266 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12077266 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:12077266 | pubmed:author | pubmed-author:CocciaEliana... | lld:pubmed |
| pubmed-article:12077266 | pubmed:author | pubmed-author:BattistiniAng... | lld:pubmed |
| pubmed-article:12077266 | pubmed:author | pubmed-author:GiacominiElen... | lld:pubmed |
| pubmed-article:12077266 | pubmed:author | pubmed-author:OreficiGrazie... | lld:pubmed |
| pubmed-article:12077266 | pubmed:author | pubmed-author:DondiElisabet... | lld:pubmed |
| pubmed-article:12077266 | pubmed:author | pubmed-author:RemoliMaria... | lld:pubmed |
| pubmed-article:12077266 | pubmed:author | pubmed-author:LutfallaGeorg... | lld:pubmed |
| pubmed-article:12077266 | pubmed:author | pubmed-author:UzéGillesG | lld:pubmed |
| pubmed-article:12077266 | pubmed:author | pubmed-author:PellegriniSan... | lld:pubmed |
| pubmed-article:12077266 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12077266 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:12077266 | pubmed:volume | 169 | lld:pubmed |
| pubmed-article:12077266 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12077266 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12077266 | pubmed:pagination | 366-74 | lld:pubmed |
| pubmed-article:12077266 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:12077266 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12077266 | pubmed:articleTitle | Selective expression of type I IFN genes in human dendritic cells infected with Mycobacterium tuberculosis. | lld:pubmed |
| pubmed-article:12077266 | pubmed:affiliation | Laboratory of Immunology, Istituto Superiore di Sanità, Rome, Italy. | lld:pubmed |
| pubmed-article:12077266 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12077266 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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