| pubmed-article:12067442 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12067442 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:12067442 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:12067442 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:12067442 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:12067442 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:12067442 | lifeskim:mentions | umls-concept:C1160185 | lld:lifeskim |
| pubmed-article:12067442 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:12067442 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:12067442 | pubmed:dateCreated | 2002-6-17 | lld:pubmed |
| pubmed-article:12067442 | pubmed:abstractText | In order to induce a therapeutic T lymphocyte response, recombinant viral vaccines are designed to target professional antigen-presenting cells (APC) such as dendritic cells (DC). A key requirement for their use in humans is safe and efficient gene delivery. The present study assesses third-generation lentivectors with respect to their ability to transduce human and mouse DC and to induce antigen-specific CD8+ T-cell responses. We demonstrate that third-generation lentivectors transduce DC with a superior efficiency compared to adenovectors. The transfer of DC transduced with a recombinant lentivector encoding an antigenic epitope resulted in a strong specific CD8+ T-cell response in mice. The occurrence of lower proportions of nonspecifically activated CD8+ cells suggests a lower antivector immunity of lentivector compared to adenovector. Thus, lentivectors, in addition to their promise for gene therapy of brain disorders might also be suitable for immunotherapy. | lld:pubmed |
| pubmed-article:12067442 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12067442 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12067442 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12067442 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12067442 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12067442 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12067442 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12067442 | pubmed:issn | 1043-0342 | lld:pubmed |
| pubmed-article:12067442 | pubmed:author | pubmed-author:RomeroPedroP | lld:pubmed |
| pubmed-article:12067442 | pubmed:author | pubmed-author:MacDonaldH... | lld:pubmed |
| pubmed-article:12067442 | pubmed:author | pubmed-author:EsslingerChri... | lld:pubmed |
| pubmed-article:12067442 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12067442 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:12067442 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:12067442 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12067442 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12067442 | pubmed:pagination | 1091-100 | lld:pubmed |
| pubmed-article:12067442 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:12067442 | pubmed:meshHeading | pubmed-meshheading:12067442... | lld:pubmed |
| pubmed-article:12067442 | pubmed:meshHeading | pubmed-meshheading:12067442... | lld:pubmed |
| pubmed-article:12067442 | pubmed:meshHeading | pubmed-meshheading:12067442... | lld:pubmed |
| pubmed-article:12067442 | pubmed:meshHeading | pubmed-meshheading:12067442... | lld:pubmed |
| pubmed-article:12067442 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12067442 | pubmed:articleTitle | Efficient transduction of dendritic cells and induction of a T-cell response by third-generation lentivectors. | lld:pubmed |
| pubmed-article:12067442 | pubmed:affiliation | Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, CH-1066 Epalinges, Switzerland. | lld:pubmed |
| pubmed-article:12067442 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12067442 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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