| pubmed-article:12065703 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12065703 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:12065703 | lifeskim:mentions | umls-concept:C0014597 | lld:lifeskim |
| pubmed-article:12065703 | lifeskim:mentions | umls-concept:C0036536 | lld:lifeskim |
| pubmed-article:12065703 | lifeskim:mentions | umls-concept:C0036537 | lld:lifeskim |
| pubmed-article:12065703 | lifeskim:mentions | umls-concept:C0458827 | lld:lifeskim |
| pubmed-article:12065703 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:12065703 | lifeskim:mentions | umls-concept:C0053800 | lld:lifeskim |
| pubmed-article:12065703 | lifeskim:mentions | umls-concept:C1159689 | lld:lifeskim |
| pubmed-article:12065703 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:12065703 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12065703 | pubmed:dateCreated | 2002-6-14 | lld:pubmed |
| pubmed-article:12065703 | pubmed:abstractText | There has been growing concern about the potential threat of hormone-disrupting chemicals like bisphenol A to various aspects of animal and human health. We studied the effects of bisphenol A on the Cl(-) secretion in human airway epithelial Calu-3 cells. Pretreatment with bisphenol A (IC(50) = 60 microM, for 30 min) prevented isoproterenol (10 nM)-generated short-circuit current (I(sc)) more potently than 17beta-estradiol or tamoxifen (IC(50) = 1 mM). 5'-Nitro-2-(3-phenylpropylamino) benzoate-sensitive apical conductance potentiated by isoproterenol was not affected by the pretreatment with either of these estrogenic compounds. The effects of bisphenol A were simulated in I(sc) responses to forskolin (10 microM) and 8-bromo-cAMP (1 mM). Nystatin permeabilization of Calu-3 monolayers revealed that bisphenol A attenuated 8-bromo-cAMP-induced basolateral K+ current, which is sensitive to clotrimazole (30 microM) and insensitive to charybdotoxin (100 nM), without affecting the apical Cl(-) current. Bisphenol A, but neither 17beta-estradiol nor tamoxifen, interrupted the charybdotoxin-sensitive component of I(sc) stimulated by 1-ethyl-2-benzimidazolinone (1-EBIO; 500 microM). The inhibitory effects of bisphenol A on these Cl(-) secretory stimuli were remarkable when applied to the apical rather than the basolateral membrane. Alternatively, long-term incubation of bisphenol A (1 microM; 12-72 h) had no discernible effect on isoproterenol- and 1-EBIO-induced Cl(-) secretion. These findings indicate that short-term exposure to bisphenol A attenuates transepithelial Cl(-) secretion through inhibition of both cAMP- and Ca(2+)-activated K+ channels on the basolateral membrane, interacting from the cytosolic surface in Calu-3 cells. | lld:pubmed |
| pubmed-article:12065703 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12065703 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065703 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12065703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065703 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12065703 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12065703 | pubmed:issn | 0022-3565 | lld:pubmed |
| pubmed-article:12065703 | pubmed:author | pubmed-author:MartinR ERE | lld:pubmed |
| pubmed-article:12065703 | pubmed:author | pubmed-author:YamakiKenichi... | lld:pubmed |
| pubmed-article:12065703 | pubmed:author | pubmed-author:KumeHiroakiH | lld:pubmed |
| pubmed-article:12065703 | pubmed:author | pubmed-author:ItoYasushiY | lld:pubmed |
| pubmed-article:12065703 | pubmed:author | pubmed-author:KondoMasashiM | lld:pubmed |
| pubmed-article:12065703 | pubmed:author | pubmed-author:SatoShinjiS | lld:pubmed |
| pubmed-article:12065703 | pubmed:author | pubmed-author:TakagiKenzoK | lld:pubmed |
| pubmed-article:12065703 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12065703 | pubmed:volume | 302 | lld:pubmed |
| pubmed-article:12065703 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12065703 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12065703 | pubmed:pagination | 80-7 | lld:pubmed |
| pubmed-article:12065703 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12065703 | pubmed:meshHeading | pubmed-meshheading:12065703... | lld:pubmed |
| pubmed-article:12065703 | pubmed:meshHeading | pubmed-meshheading:12065703... | lld:pubmed |
| pubmed-article:12065703 | pubmed:meshHeading | pubmed-meshheading:12065703... | lld:pubmed |
| pubmed-article:12065703 | pubmed:meshHeading | pubmed-meshheading:12065703... | lld:pubmed |
| pubmed-article:12065703 | pubmed:meshHeading | pubmed-meshheading:12065703... | lld:pubmed |
| pubmed-article:12065703 | pubmed:meshHeading | pubmed-meshheading:12065703... | lld:pubmed |
| pubmed-article:12065703 | pubmed:meshHeading | pubmed-meshheading:12065703... | lld:pubmed |
| pubmed-article:12065703 | pubmed:meshHeading | pubmed-meshheading:12065703... | lld:pubmed |
| pubmed-article:12065703 | pubmed:meshHeading | pubmed-meshheading:12065703... | lld:pubmed |
| pubmed-article:12065703 | pubmed:meshHeading | pubmed-meshheading:12065703... | lld:pubmed |
| pubmed-article:12065703 | pubmed:meshHeading | pubmed-meshheading:12065703... | lld:pubmed |
| pubmed-article:12065703 | pubmed:meshHeading | pubmed-meshheading:12065703... | lld:pubmed |
| pubmed-article:12065703 | pubmed:meshHeading | pubmed-meshheading:12065703... | lld:pubmed |
| pubmed-article:12065703 | pubmed:meshHeading | pubmed-meshheading:12065703... | lld:pubmed |
| pubmed-article:12065703 | pubmed:meshHeading | pubmed-meshheading:12065703... | lld:pubmed |
| pubmed-article:12065703 | pubmed:meshHeading | pubmed-meshheading:12065703... | lld:pubmed |
| pubmed-article:12065703 | pubmed:meshHeading | pubmed-meshheading:12065703... | lld:pubmed |
| pubmed-article:12065703 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12065703 | pubmed:articleTitle | Bisphenol A inhibits Cl(-) secretion by inhibition of basolateral K+ conductance in human airway epithelial cells. | lld:pubmed |
| pubmed-article:12065703 | pubmed:affiliation | Division II (Respiratory Division), Internal Medicine II, University of Nagoya School of Medicine, Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. | lld:pubmed |
| pubmed-article:12065703 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12065703 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12065703 | lld:pubmed |
