| pubmed-article:12060103 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12060103 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:12060103 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:12060103 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:12060103 | lifeskim:mentions | umls-concept:C0206117 | lld:lifeskim |
| pubmed-article:12060103 | lifeskim:mentions | umls-concept:C0025465 | lld:lifeskim |
| pubmed-article:12060103 | lifeskim:mentions | umls-concept:C1511545 | lld:lifeskim |
| pubmed-article:12060103 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:12060103 | pubmed:dateCreated | 2002-6-12 | lld:pubmed |
| pubmed-article:12060103 | pubmed:abstractText | 1. Acetylcholine (ACh) evokes endothelium-dependent hyperpolarization in arterial cells, presumably through endothelium-derived hyperpolarizing factor (EDHF). The identity of EDHF is still elusive; however, several recent studies suggest the possible involvement of myoendothelial gap junctions in the EDHF response. 2. To elucidate the role of gap junctions in endothelium-dependent hyperpolarization, we examined the effects of the gap junction inhibitors 18 alpha-glycyrrhetinic acid (18 alpha-GA; 10(-4) mol/L) and carbenoxolone (3 x 10(-4) mol/L), a water-soluble form of 18 beta-GA, on hyperpolarization and relaxation to ACh in rat proximal and distal mesenteric arteries. Experiments were performed in the presence of indomethacin (10(-5) mol/L) and N(G)-nitro-L-arginine (10(-4) mol/L). 3. In both proximal and distal mesenteric arteries, ACh-induced hyperpolarization and relaxation were partially inhibited by 18 alpha-GA and abolished by carbenoxolone. 4. Endothelium-independent hyperpolarization to levcromakalim, an ATP-sensitive K+ channel opener, were unaffected by 18 alpha-GA or carbenoxolone in both arteries. 5. Relaxations to levcromakalim were unaffected by 18 alpha-GA, but were inhibited somewhat by carbenoxolone in proximal mesenteric arteries. 6. These findings suggest that myoendothelial gap junctions play a critical role in EDHF-mediated responses in both proximal and distal mesenteric arteries of the rat. | lld:pubmed |
| pubmed-article:12060103 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12060103 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12060103 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12060103 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12060103 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12060103 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12060103 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12060103 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12060103 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12060103 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12060103 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12060103 | pubmed:issn | 0305-1870 | lld:pubmed |
| pubmed-article:12060103 | pubmed:author | pubmed-author:KansuiYasuoY | lld:pubmed |
| pubmed-article:12060103 | pubmed:author | pubmed-author:FujiiKojiK | lld:pubmed |
| pubmed-article:12060103 | pubmed:author | pubmed-author:GotoKenichiK | lld:pubmed |
| pubmed-article:12060103 | pubmed:author | pubmed-author:AbeIsaoI | lld:pubmed |
| pubmed-article:12060103 | pubmed:author | pubmed-author:IidaMitsuoM | lld:pubmed |
| pubmed-article:12060103 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12060103 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:12060103 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12060103 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12060103 | pubmed:pagination | 595-602 | lld:pubmed |
| pubmed-article:12060103 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12060103 | pubmed:meshHeading | pubmed-meshheading:12060103... | lld:pubmed |
| pubmed-article:12060103 | pubmed:meshHeading | pubmed-meshheading:12060103... | lld:pubmed |
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| pubmed-article:12060103 | pubmed:meshHeading | pubmed-meshheading:12060103... | lld:pubmed |
| pubmed-article:12060103 | pubmed:meshHeading | pubmed-meshheading:12060103... | lld:pubmed |
| pubmed-article:12060103 | pubmed:meshHeading | pubmed-meshheading:12060103... | lld:pubmed |
| pubmed-article:12060103 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12060103 | pubmed:articleTitle | Critical role of gap junctions in endothelium-dependent hyperpolarization in rat mesenteric arteries. | lld:pubmed |
| pubmed-article:12060103 | pubmed:affiliation | Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. | lld:pubmed |
| pubmed-article:12060103 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12060103 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:12060103 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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