| pubmed-article:12055240 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12055240 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:12055240 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:12055240 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:12055240 | lifeskim:mentions | umls-concept:C0441471 | lld:lifeskim |
| pubmed-article:12055240 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:12055240 | lifeskim:mentions | umls-concept:C1332700 | lld:lifeskim |
| pubmed-article:12055240 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:12055240 | lifeskim:mentions | umls-concept:C0011155 | lld:lifeskim |
| pubmed-article:12055240 | lifeskim:mentions | umls-concept:C1332690 | lld:lifeskim |
| pubmed-article:12055240 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:12055240 | lifeskim:mentions | umls-concept:C1332691 | lld:lifeskim |
| pubmed-article:12055240 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:12055240 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:12055240 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:12055240 | lifeskim:mentions | umls-concept:C1579373 | lld:lifeskim |
| pubmed-article:12055240 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:12055240 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:12055240 | pubmed:dateCreated | 2002-6-10 | lld:pubmed |
| pubmed-article:12055240 | pubmed:abstractText | Human memory CD4(+) T cells respond better to inflammatory CCLs/CC chemokines, CCL3 and CCL5, than naive CD4(+) T cells. We analyzed the regulatory mechanism underlying this difference. Memory and naive CD4(+) T cells expressed similarly high levels of CCR1; however, CCR5 was only expressed in memory CD4(+) T cells at low levels. Experiments using mAbs to block chemokine receptors revealed that CCR1 functioned as a major receptor for the binding of CCL5 in memory and naive CD4(+) T cells as well as the ligand-induced chemotaxis in memory CD4(+) T cells. Stimulation of memory CD4(+) T cells with CCL5 activated protein tyrosine kinase-dependent cascades, which were significantly blocked by anti-CCR1 mAb, whereas this stimulation failed to induce these events in naive CD4(+) T cells. Intracellular expressions of regulator of G protein signaling 3 and 4 were only detected in naive CD4(+) T cells. Pretreatment of cell membrane fractions from memory and naive CD4(+) T cells with GTP-gamma S inhibited CCL5 binding, indicating the involvement of G proteins in the interaction of CCL5 and its receptor(s). In contrast, CCL5 enhanced the GTP binding to G(i alpha) and G(q alpha) in memory CD4(+) T cells, but not in naive CD4(+) T cells. Thus, a failure of the ligand-induced activation of CCR1-mediated downstream signaling event as well as a deficiency of CCR5 expression may be involved in the hyporesponsiveness of naive CD4(+) T cells to CCL3 and CCL5. | lld:pubmed |
| pubmed-article:12055240 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12055240 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12055240 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:12055240 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12055240 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12055240 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12055240 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12055240 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12055240 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12055240 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12055240 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12055240 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12055240 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12055240 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12055240 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12055240 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12055240 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12055240 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12055240 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:12055240 | pubmed:author | pubmed-author:MorimotoChika... | lld:pubmed |
| pubmed-article:12055240 | pubmed:author | pubmed-author:KawasakiHiros... | lld:pubmed |
| pubmed-article:12055240 | pubmed:author | pubmed-author:SatoKatsuakiK | lld:pubmed |
| pubmed-article:12055240 | pubmed:author | pubmed-author:YamashimaNaoh... | lld:pubmed |
| pubmed-article:12055240 | pubmed:author | pubmed-author:MatsuyamaTaka... | lld:pubmed |
| pubmed-article:12055240 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12055240 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:12055240 | pubmed:volume | 168 | lld:pubmed |
| pubmed-article:12055240 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12055240 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12055240 | pubmed:pagination | 6263-72 | lld:pubmed |
| pubmed-article:12055240 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:12055240 | pubmed:meshHeading | pubmed-meshheading:12055240... | lld:pubmed |
| pubmed-article:12055240 | pubmed:meshHeading | pubmed-meshheading:12055240... | lld:pubmed |
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| pubmed-article:12055240 | pubmed:meshHeading | pubmed-meshheading:12055240... | lld:pubmed |
| pubmed-article:12055240 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12055240 | pubmed:articleTitle | An abortive ligand-induced activation of CCR1-mediated downstream signaling event and a deficiency of CCR5 expression are associated with the hyporesponsiveness of human naive CD4+ T cells to CCL3 and CCL5. | lld:pubmed |
| pubmed-article:12055240 | pubmed:affiliation | Department of Immunology and Medical Zoology, School of Medicine, Kagoshima University, Sakuragaoka, Kagoshima, Japan. katusaki@m3.kufm.kagoshima-u.ac.jp | lld:pubmed |
| pubmed-article:12055240 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12055240 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:12055240 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12055240 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12055240 | lld:pubmed |
