| pubmed-article:12032091 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12032091 | lifeskim:mentions | umls-concept:C0011065 | lld:lifeskim |
| pubmed-article:12032091 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:12032091 | lifeskim:mentions | umls-concept:C1546956 | lld:lifeskim |
| pubmed-article:12032091 | lifeskim:mentions | umls-concept:C1413931 | lld:lifeskim |
| pubmed-article:12032091 | lifeskim:mentions | umls-concept:C0752526 | lld:lifeskim |
| pubmed-article:12032091 | lifeskim:mentions | umls-concept:C0163630 | lld:lifeskim |
| pubmed-article:12032091 | lifeskim:mentions | umls-concept:C0179400 | lld:lifeskim |
| pubmed-article:12032091 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:12032091 | pubmed:dateCreated | 2002-5-28 | lld:pubmed |
| pubmed-article:12032091 | pubmed:abstractText | An important control step in the regulation of cytoplasmic mRNA turnover is the removal of the m(7)G cap structure at the 5' end of the message. Here, we describe the functional characterization of Dhh1, a highly conserved member of the family of DEAD box-containing proteins, as a regulator of mRNA decapping in Saccharomyces cerevisiae. Dhh1 is a cytoplasmic protein and is shown to be in a complex with the mRNA degradation factor Pat1/Mtr1 and with the 5'-3' exoribonuclease Xrn1. Dhh1 specifically affects mRNA turnover in the deadenylation-dependent decay pathway, but does not act on the degradation of nonsense-containing mRNAs. Cells that lack dhh1 accumulate degradation intermediates that have lost their poly(A) tail but contain an intact 5' cap structure, suggesting that Dhh1 is required for efficient decapping in vivo. Furthermore, recombinant Dhh1 is able to stimulate the activity of the purified decapping enzyme Dcp1 in an in vitro decapping assay. We propose that the DEAD box protein Dhh1 regulates the access of the decapping enzyme to the m(7)G cap by modulating the structure at the 5' end of mRNAs. | lld:pubmed |
| pubmed-article:12032091 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12032091 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12032091 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032091 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12032091 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12032091 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:12032091 | pubmed:author | pubmed-author:WeisKarstenK | lld:pubmed |
| pubmed-article:12032091 | pubmed:author | pubmed-author:FischerNicole... | lld:pubmed |
| pubmed-article:12032091 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12032091 | pubmed:day | 3 | lld:pubmed |
