| pubmed-article:12031663 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12031663 | lifeskim:mentions | umls-concept:C0030657 | lld:lifeskim |
| pubmed-article:12031663 | lifeskim:mentions | umls-concept:C0525026 | lld:lifeskim |
| pubmed-article:12031663 | lifeskim:mentions | umls-concept:C0034760 | lld:lifeskim |
| pubmed-article:12031663 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:12031663 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:12031663 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:12031663 | lifeskim:mentions | umls-concept:C1510800 | lld:lifeskim |
| pubmed-article:12031663 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:12031663 | pubmed:dateCreated | 2002-5-28 | lld:pubmed |
| pubmed-article:12031663 | pubmed:abstractText | We have explored a novel strategy for controlling the infectivity of adenoviral vectors. This strategy involves a method whereby the infectivity of adenoviral vectors is neutralized by treatment of viral particles with a water-soluble, photocleavable biotinylation reagent. These modified viral vectors possess little to no infectivity for target cells. Exposure of these modified viral vectors to 365 nm light induces a reversal of the neutralizing, chemical modification, resulting in restoration of infectivity to the viral vectors. The light-directed transduction of target cells by photoactivatable adenoviral vectors was demonstrated successfully both in vitro and in vivo. This photochemical infectivity trigger possesses great potential, both as a research tool and as a novel tactic for the delivery of gene-transfer agents, since the infectivity of adenoviral vectors can be controlled externally in a versatile manner. | lld:pubmed |
| pubmed-article:12031663 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12031663 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12031663 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12031663 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12031663 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12031663 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12031663 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12031663 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12031663 | pubmed:month | May | lld:pubmed |
| pubmed-article:12031663 | pubmed:issn | 1074-5521 | lld:pubmed |
| pubmed-article:12031663 | pubmed:author | pubmed-author:PalmerAbraham... | lld:pubmed |
| pubmed-article:12031663 | pubmed:author | pubmed-author:PhillipsTamar... | lld:pubmed |
| pubmed-article:12031663 | pubmed:author | pubmed-author:PandoriMark... | lld:pubmed |
| pubmed-article:12031663 | pubmed:author | pubmed-author:SanoTakeshiT | lld:pubmed |
| pubmed-article:12031663 | pubmed:author | pubmed-author:HobsonDavid... | lld:pubmed |
| pubmed-article:12031663 | pubmed:author | pubmed-author:OlejnikJerzyJ | lld:pubmed |
| pubmed-article:12031663 | pubmed:author | pubmed-author:Krzymanska-Ol... | lld:pubmed |
| pubmed-article:12031663 | pubmed:author | pubmed-author:RothschildKen... | lld:pubmed |
| pubmed-article:12031663 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12031663 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:12031663 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12031663 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12031663 | pubmed:pagination | 567-73 | lld:pubmed |
| pubmed-article:12031663 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:12031663 | pubmed:meshHeading | pubmed-meshheading:12031663... | lld:pubmed |
| pubmed-article:12031663 | pubmed:meshHeading | pubmed-meshheading:12031663... | lld:pubmed |
| pubmed-article:12031663 | pubmed:meshHeading | pubmed-meshheading:12031663... | lld:pubmed |
| pubmed-article:12031663 | pubmed:meshHeading | pubmed-meshheading:12031663... | lld:pubmed |
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| pubmed-article:12031663 | pubmed:meshHeading | pubmed-meshheading:12031663... | lld:pubmed |
| pubmed-article:12031663 | pubmed:meshHeading | pubmed-meshheading:12031663... | lld:pubmed |
| pubmed-article:12031663 | pubmed:meshHeading | pubmed-meshheading:12031663... | lld:pubmed |
| pubmed-article:12031663 | pubmed:meshHeading | pubmed-meshheading:12031663... | lld:pubmed |
| pubmed-article:12031663 | pubmed:meshHeading | pubmed-meshheading:12031663... | lld:pubmed |
| pubmed-article:12031663 | pubmed:meshHeading | pubmed-meshheading:12031663... | lld:pubmed |
| pubmed-article:12031663 | pubmed:meshHeading | pubmed-meshheading:12031663... | lld:pubmed |
| pubmed-article:12031663 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12031663 | pubmed:articleTitle | Photochemical control of the infectivity of adenoviral vectors using a novel photocleavable biotinylation reagent. | lld:pubmed |
| pubmed-article:12031663 | pubmed:affiliation | Center for Molecular Imaging Diagnosis and Therapy and Basic Science Laboratory, Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. | lld:pubmed |
| pubmed-article:12031663 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12031663 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12031663 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12031663 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12031663 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12031663 | lld:pubmed |
