Linked Life Data

12021347

Source:http://linkedlifedata.com/resource/pubmed/id/12021347

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:12021347rdf:typepubmed:Citationlld:pubmed
pubmed-article:12021347lifeskim:mentionsumls-concept:C0042216lld:lifeskim
pubmed-article:12021347lifeskim:mentionsumls-concept:C0522424lld:lifeskim
pubmed-article:12021347lifeskim:mentionsumls-concept:C0035820lld:lifeskim
pubmed-article:12021347lifeskim:mentionsumls-concept:C0012854lld:lifeskim
pubmed-article:12021347lifeskim:mentionsumls-concept:C0042210lld:lifeskim
pubmed-article:12021347lifeskim:mentionsumls-concept:C0805586lld:lifeskim
pubmed-article:12021347lifeskim:mentionsumls-concept:C2587213lld:lifeskim
pubmed-article:12021347lifeskim:mentionsumls-concept:C0205349lld:lifeskim
pubmed-article:12021347lifeskim:mentionsumls-concept:C1511545lld:lifeskim
pubmed-article:12021347pubmed:issue12lld:pubmed
pubmed-article:12021347pubmed:dateCreated2002-5-21lld:pubmed
pubmed-article:12021347pubmed:abstractTextCellular immune responses against epitopes in conserved Gag and Pol sequences of human immunodeficiency virus type 1 have become popular targets for candidate AIDS vaccines. Recently, we used a simian-human immunodeficiency virus model (SHIV 89.6P) with macaques to demonstrate the control of a pathogenic mucosal challenge by priming with Gag-Pol-Env-expressing DNA and boosting with Gag-Pol-Env-expressing recombinant modified vaccinia virus Ankara (rMVA). Here we tested Gag-Pol DNA priming and Gag-Pol rMVA boosting to evaluate the contribution of anti-Env immune responses to viral control. The Gag-Pol vaccine raised frequencies of Gag-specific T cells similar to those raised by the Gag-Pol-Env vaccine. Following challenge, these rapidly expanded to counter the challenge infection. Despite this, the control of the SHIV 89.6P challenge was delayed and inconsistent in the Gag-Pol-vaccinated group and all of the animals underwent severe and, in most cases, sustained loss of CD4(+) cells. Interestingly, most of the CD4(+) cells that were lost in the Gag-Pol-vaccinated group were uninfected cells. We suggest that the rapid appearance of binding antibody for Env in Gag-Pol-Env-vaccinated animals helped protect uninfected CD4(+) cells from Env-induced apoptosis. Our results highlight the importance of immune responses to Env, as well as to Gag-Pol, in the control of immunodeficiency virus challenges and the protection of CD4(+) cells.lld:pubmed
pubmed-article:12021347pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12021347pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12021347pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12021347pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12021347pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12021347pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12021347pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12021347pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12021347pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12021347pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12021347pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12021347pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12021347pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12021347pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12021347pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12021347pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12021347pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12021347pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12021347pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12021347pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12021347pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12021347pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12021347pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12021347pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12021347pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12021347pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12021347pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12021347pubmed:languageenglld:pubmed
pubmed-article:12021347pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12021347pubmed:citationSubsetIMlld:pubmed
pubmed-article:12021347pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12021347pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12021347pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12021347pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12021347pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12021347pubmed:statusMEDLINElld:pubmed
pubmed-article:12021347pubmed:monthJunlld:pubmed
pubmed-article:12021347pubmed:issn0022-538Xlld:pubmed
pubmed-article:12021347pubmed:authorpubmed-author:KlosIu SIuSlld:pubmed
pubmed-article:12021347pubmed:authorpubmed-author:McClureHarold...lld:pubmed
pubmed-article:12021347pubmed:authorpubmed-author:MontefioriDav...lld:pubmed
pubmed-article:12021347pubmed:authorpubmed-author:MossBernardBlld:pubmed
pubmed-article:12021347pubmed:authorpubmed-author:AltmanJohn...lld:pubmed
pubmed-article:12021347pubmed:authorpubmed-author:VillingerFran...lld:pubmed
pubmed-article:12021347pubmed:authorpubmed-author:StapransSilvi...lld:pubmed
pubmed-article:12021347pubmed:authorpubmed-author:SmithJames...lld:pubmed
pubmed-article:12021347pubmed:authorpubmed-author:AmaraRama...lld:pubmed
pubmed-article:12021347pubmed:authorpubmed-author:O'NeilShawn...lld:pubmed
pubmed-article:12021347pubmed:authorpubmed-author:HerndonJames...lld:pubmed
pubmed-article:12021347pubmed:authorpubmed-author:WyattLinda...lld:pubmed
pubmed-article:12021347pubmed:authorpubmed-author:KozyrNatalia...lld:pubmed
pubmed-article:12021347pubmed:authorpubmed-author:EarlPatricia...lld:pubmed
pubmed-article:12021347pubmed:authorpubmed-author:McNichollJane...lld:pubmed
pubmed-article:12021347pubmed:authorpubmed-author:RobinsonHarri...lld:pubmed
pubmed-article:12021347pubmed:issnTypePrintlld:pubmed
pubmed-article:12021347pubmed:volume76lld:pubmed
pubmed-article:12021347pubmed:ownerNLMlld:pubmed
pubmed-article:12021347pubmed:authorsCompleteYlld:pubmed
pubmed-article:12021347pubmed:pagination6138-46lld:pubmed
pubmed-article:12021347pubmed:dateRevised2009-11-18lld:pubmed
pubmed-article:12021347pubmed:meshHeadingpubmed-meshheading:12021347...lld:pubmed
pubmed-article:12021347pubmed:meshHeadingpubmed-meshheading:12021347...lld:pubmed
pubmed-article:12021347pubmed:meshHeadingpubmed-meshheading:12021347...lld:pubmed
pubmed-article:12021347pubmed:meshHeadingpubmed-meshheading:12021347...lld:pubmed
pubmed-article:12021347pubmed:meshHeadingpubmed-meshheading:12021347...lld:pubmed
pubmed-article:12021347pubmed:meshHeadingpubmed-meshheading:12021347...lld:pubmed
pubmed-article:12021347pubmed:meshHeadingpubmed-meshheading:12021347...lld:pubmed
pubmed-article:12021347pubmed:meshHeadingpubmed-meshheading:12021347...lld:pubmed
pubmed-article:12021347pubmed:meshHeadingpubmed-meshheading:12021347...lld:pubmed
pubmed-article:12021347pubmed:meshHeadingpubmed-meshheading:12021347...lld:pubmed
pubmed-article:12021347pubmed:meshHeadingpubmed-meshheading:12021347...lld:pubmed
pubmed-article:12021347pubmed:meshHeadingpubmed-meshheading:12021347...lld:pubmed
pubmed-article:12021347pubmed:meshHeadingpubmed-meshheading:12021347...lld:pubmed
pubmed-article:12021347pubmed:meshHeadingpubmed-meshheading:12021347...lld:pubmed
pubmed-article:12021347pubmed:meshHeadingpubmed-meshheading:12021347...lld:pubmed
pubmed-article:12021347pubmed:year2002lld:pubmed
pubmed-article:12021347pubmed:articleTitleCritical role for Env as well as Gag-Pol in control of a simian-human immunodeficiency virus 89.6P challenge by a DNA prime/recombinant modified vaccinia virus Ankara vaccine.lld:pubmed
pubmed-article:12021347pubmed:affiliationVaccine Research Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA.lld:pubmed
pubmed-article:12021347pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12021347pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12021347lld:pubmed
More...