Linked Life Data

12011966

Source:http://linkedlifedata.com/resource/pubmed/id/12011966

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pubmed-article:12011966pubmed:abstractTextThe aim of this study was to demonstrate whether HR (Paroven-Venoruton; 0-(beta-hydroxyethyl)-rutosides), was effective in improving the microcirculation in venous hypertension and microangiopathy. Sixty patients with severe venous hypertension due to chronic venous insufficiency, ankle swelling, and lipodermatosclerosis were included. After informed consent, patients were randomized into a treatment group and a placebo group. Patients in the treatment group received oral HR (2 g/day for 8 weeks); those in the placebo group received a comparable placebo. RESULTS: The two groups were comparable for age and sex distribution. The mean age was 45 years (SD 9) in the treatment group (31 patients) and 45.5 (SD 10) in the placebo group (29 patients). There were no differences between the placebo and treatment groups at inclusion. There was no change between inclusion and measurements at 8 weeks in the placebo group. A significant decrease (P < 0.05) in flux at rest and rate of ankle swelling was observed in the treatment group. The decrease in capillary filtration was associated with improvement in signs and symptoms (P < 0.05). The difference in flux, sign and symptoms, and filtration was clinically important at 8 weeks in the treatment group when compared with the placebo group. No adverse effects were observed. CONCLUSION: Venous microangiopathy was improved by HR treatment.lld:pubmed
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pubmed-article:12011966pubmed:dateRevised2004-11-17lld:pubmed
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pubmed-article:12011966pubmed:articleTitleHR (Paroven, Venoruton; 0-(beta-hydroxyethyl)-rutosides) in venous hypertensive microangiopathy: a prospective, placebo-controlled, randomized trial.lld:pubmed
pubmed-article:12011966pubmed:affiliationIrvine2 Vasc Lab and Physiology, Department of Biomedical Sciences, Chieti University, San Valentino Vascular Screening Project, Italy.lld:pubmed
pubmed-article:12011966pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12011966pubmed:publicationTypeClinical Triallld:pubmed
pubmed-article:12011966pubmed:publicationTypeRandomized Controlled Triallld:pubmed