| pubmed-article:12007724 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12007724 | lifeskim:mentions | umls-concept:C0011860 | lld:lifeskim |
| pubmed-article:12007724 | lifeskim:mentions | umls-concept:C0033085 | lld:lifeskim |
| pubmed-article:12007724 | lifeskim:mentions | umls-concept:C0030274 | lld:lifeskim |
| pubmed-article:12007724 | lifeskim:mentions | umls-concept:C0242606 | lld:lifeskim |
| pubmed-article:12007724 | lifeskim:mentions | umls-concept:C0033215 | lld:lifeskim |
| pubmed-article:12007724 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:12007724 | lifeskim:mentions | umls-concept:C0301630 | lld:lifeskim |
| pubmed-article:12007724 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12007724 | pubmed:dateCreated | 2002-5-14 | lld:pubmed |
| pubmed-article:12007724 | pubmed:abstractText | Oxidative stress is induced under diabetic conditions and causes various forms of tissue damage in patients with diabetes. Recently, pancreatic beta-cells have emerged as a putative target of oxidative stress-induced tissue damage and this seems to explain in part the progressive deterioration of beta-cell function in type 2 diabetes. As a step toward clinical trial of antioxidant for type 2 diabetes, we investigated the possible anti-diabetic effects of probucol, an antioxidant widely used as an anti-hyperlipidemic agent, on preservation of beta-cell function in diabetic C57BL/KsJ-db/db mice. Probucol-containing diet was given to mice from 6 to 16 weeks of age. Immunostaining for oxidative stress markers such as 4-hydroxy-2-nonenal (HNE)-modified proteins and heme oxygenase-1 revealed that probucol treatment decreased reactive oxygen species (ROS) in pancreatic islets of diabetic animals. Oxidative stress is known to enhance apoptosis of beta-cells and to suppress insulin biosynthesis, but probucol treatment led to preservation of beta-cell mass and the insulin content. According to intraperitoneal glucose tolerance tests, the probucol treatment preserved glucose-stimulated insulin secretion and improved glucose tolerance at 10 and 16 weeks: insulin, 280+/-82 vs. 914+/-238 pmol/l (120 min, at 16 weeks; P<0.05); glucose, 44.6+/-2.4 vs. 35.2+/-2.6 mmol/l (120 min, at 16 weeks; P<0.05). Thus, our present observations demonstrate the potential usefulness of probucol for treatment of type 2 diabetes. | lld:pubmed |
| pubmed-article:12007724 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12007724 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12007724 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12007724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12007724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12007724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12007724 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12007724 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12007724 | pubmed:issn | 0168-8227 | lld:pubmed |
| pubmed-article:12007724 | pubmed:author | pubmed-author:KanetoHideaki... | lld:pubmed |
| pubmed-article:12007724 | pubmed:author | pubmed-author:HoriMasatsugu... | lld:pubmed |
| pubmed-article:12007724 | pubmed:author | pubmed-author:YasudaTetsuyu... | lld:pubmed |
| pubmed-article:12007724 | pubmed:author | pubmed-author:KajimotoYoshi... | lld:pubmed |
| pubmed-article:12007724 | pubmed:author | pubmed-author:WatadaHirotak... | lld:pubmed |
| pubmed-article:12007724 | pubmed:author | pubmed-author:UmayaharaYuta... | lld:pubmed |
| pubmed-article:12007724 | pubmed:author | pubmed-author:MatsuhisaMune... | lld:pubmed |
| pubmed-article:12007724 | pubmed:author | pubmed-author:YamasakiYoshi... | lld:pubmed |
| pubmed-article:12007724 | pubmed:author | pubmed-author:KurodaAkioA | lld:pubmed |
| pubmed-article:12007724 | pubmed:author | pubmed-author:KawamoriDanD | lld:pubmed |
| pubmed-article:12007724 | pubmed:author | pubmed-author:GorogawaShin... | lld:pubmed |
| pubmed-article:12007724 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12007724 | pubmed:volume | 57 | lld:pubmed |
| pubmed-article:12007724 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12007724 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12007724 | pubmed:pagination | 1-10 | lld:pubmed |
| pubmed-article:12007724 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:12007724 | pubmed:meshHeading | pubmed-meshheading:12007724... | lld:pubmed |
| pubmed-article:12007724 | pubmed:meshHeading | pubmed-meshheading:12007724... | lld:pubmed |
| pubmed-article:12007724 | pubmed:meshHeading | pubmed-meshheading:12007724... | lld:pubmed |
| pubmed-article:12007724 | pubmed:meshHeading | pubmed-meshheading:12007724... | lld:pubmed |
| pubmed-article:12007724 | pubmed:meshHeading | pubmed-meshheading:12007724... | lld:pubmed |
| pubmed-article:12007724 | pubmed:meshHeading | pubmed-meshheading:12007724... | lld:pubmed |
| pubmed-article:12007724 | pubmed:meshHeading | pubmed-meshheading:12007724... | lld:pubmed |
| pubmed-article:12007724 | pubmed:meshHeading | pubmed-meshheading:12007724... | lld:pubmed |
| pubmed-article:12007724 | pubmed:meshHeading | pubmed-meshheading:12007724... | lld:pubmed |
| pubmed-article:12007724 | pubmed:meshHeading | pubmed-meshheading:12007724... | lld:pubmed |
| pubmed-article:12007724 | pubmed:meshHeading | pubmed-meshheading:12007724... | lld:pubmed |
| pubmed-article:12007724 | pubmed:meshHeading | pubmed-meshheading:12007724... | lld:pubmed |
| pubmed-article:12007724 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12007724 | pubmed:articleTitle | Probucol preserves pancreatic beta-cell function through reduction of oxidative stress in type 2 diabetes. | lld:pubmed |
| pubmed-article:12007724 | pubmed:affiliation | Department of Internal Medicine and Therapeutics (A8), Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita City, Osaka Pref, Japan. | lld:pubmed |
| pubmed-article:12007724 | pubmed:publicationType | Journal Article | lld:pubmed |
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