| pubmed-article:11997390 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11997390 | lifeskim:mentions | umls-concept:C0010762 | lld:lifeskim |
| pubmed-article:11997390 | lifeskim:mentions | umls-concept:C0042874 | lld:lifeskim |
| pubmed-article:11997390 | lifeskim:mentions | umls-concept:C0051169 | lld:lifeskim |
| pubmed-article:11997390 | lifeskim:mentions | umls-concept:C0087096 | lld:lifeskim |
| pubmed-article:11997390 | lifeskim:mentions | umls-concept:C0449438 | lld:lifeskim |
| pubmed-article:11997390 | lifeskim:mentions | umls-concept:C0699900 | lld:lifeskim |
| pubmed-article:11997390 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:11997390 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:11997390 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:11997390 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:11997390 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:11997390 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:11997390 | pubmed:issue | 28 | lld:pubmed |
| pubmed-article:11997390 | pubmed:dateCreated | 2002-7-8 | lld:pubmed |
| pubmed-article:11997390 | pubmed:abstractText | Postabsorptive elimination of the various forms of vitamin E appears to play a key role in regulation of tissue tocopherol concentrations, but mechanisms of tocopherol metabolism have not been elucidated. Here we describe a pathway involving cytochrome P450-mediated omega-hydroxylation of the tocopherol phytyl side chain followed by stepwise removal of two- or three-carbon moieties, ultimately yielding the 3'-carboxychromanol metabolite that is excreted in urine. All key intermediates of gamma-tocopherol metabolism via this pathway were identified in hepatocyte cultures using gas chromatography-mass spectrometry. NADPH-dependent synthesis of the initial gamma- and alpha-tocopherol 13'-hydroxy and -carboxy metabolites was demonstrated in rat and human liver microsomes. Functional analysis of several recombinant human liver P450 enzymes revealed that tocopherol-omega-hydroxylase activity was associated only with CYP4F2, which also catalyzes omega-hydroxylation of leukotriene B(4) and arachidonic acid. Tocopherol-omega-hydroxylase exhibited similar binding affinities but markedly higher catalytic activities for gamma-tocopherol than alpha-tocopherol, suggesting a role for this pathway in the preferential physiological retention of alpha-tocopherol and elimination of gamma-tocopherol. Sesamin potently inhibited tocopherol-omega-hydroxylase activity exhibited by CYP4F2 and rat or human liver microsomes. Since dietary sesamin also results in elevated tocopherol levels in vivo, this pathway appears to represent a functionally significant means of regulating vitamin E status. | lld:pubmed |
| pubmed-article:11997390 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11997390 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11997390 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11997390 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11997390 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11997390 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:11997390 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:11997390 | pubmed:author | pubmed-author:ParkerRobert... | lld:pubmed |
| pubmed-article:11997390 | pubmed:author | pubmed-author:SontagTimothy... | lld:pubmed |
| pubmed-article:11997390 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11997390 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:11997390 | pubmed:volume | 277 | lld:pubmed |
| pubmed-article:11997390 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11997390 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11997390 | pubmed:pagination | 25290-6 | lld:pubmed |
| pubmed-article:11997390 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:11997390 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11997390 | pubmed:articleTitle | Cytochrome P450 omega-hydroxylase pathway of tocopherol catabolism. Novel mechanism of regulation of vitamin E status. | lld:pubmed |
| pubmed-article:11997390 | pubmed:affiliation | Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA. | lld:pubmed |
| pubmed-article:11997390 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11997390 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11997390 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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