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pubmed-article:11990921pubmed:abstractTextPolymorphonuclear leukocytes (PMN) and tumor necrosis factor-alpha (TNF-alpha) play prominent roles in acute respiratory distress syndrome, ischemia-reperfusion injury, trauma, and sepsis. Whereas direct effects of TNF-alpha on PMN function and viability are well documented, little data are available addressing the ability of PMN to communicate with each other in response to cytokine stimulation. Therefore, the aim of this study was to determine whether TNF-alpha can modulate PMN function by inducing PMN to secrete products upon stimulation, which would affect other PMN in vitro in a manner independent of cell contact.lld:pubmed
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pubmed-article:11990921pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:11990921pubmed:articleTitleTumor necrosis factor-alpha-stimulated polymorphonuclear leukocytes suppress migration and bactericidal activity of polymorphonuclear leukocytes in a paracrine manner.lld:pubmed
pubmed-article:11990921pubmed:affiliationDivision of Surgical Research, Rhode Island Hospital, and Brown University School of Medicine, Providence, USA.lld:pubmed
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