| pubmed-article:11972636 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11972636 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:11972636 | lifeskim:mentions | umls-concept:C0023861 | lld:lifeskim |
| pubmed-article:11972636 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:11972636 | lifeskim:mentions | umls-concept:C1155065 | lld:lifeskim |
| pubmed-article:11972636 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:11972636 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:11972636 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11972636 | pubmed:dateCreated | 2002-4-25 | lld:pubmed |
| pubmed-article:11972636 | pubmed:abstractText | Listeria monocytogenes infection of mice leads to a rapid expansion of activated T cells, followed by a decline in specific cells once the bacteria are eliminated. In order to define the relationship between T-cell proliferation and activation, and to investigate the role of apoptosis in limiting the expansion, the expression of activation markers, uptake of 5-bromo-2'-deoxyuridine (BrdU) in vivo and the incidence of apoptosis was investigated. Increased numbers of T cells expressing the activated phenotype CD25+, CD44hi and CD62Llo were detected 4 days after infection. Expression of CD25 (IL-2Ralpha chain) on CD4+ and CD8+ T cells peaked at this time and returned to normal by day 7. In contrast, CD44hi and CD62Llo persisted, with the maximum proportion occurring at 7 days after infection. This was accompanied by a burst of in vivo proliferation of CD4+ and CD8+ T cells occurring between day 5 and 7. Apoptosis, which is presumably needed to control this expansion of T cells, also peaked at 7 days after infection. Apoptosis occurred preferentially amongst T cells which had proliferated. Most but not all proliferating T cells had down-regulated their CD62L marker. While most apoptotic T cells were CD62Llo, again not all had down-regulated this marker. Hence, CD25 expression peaked early, but expression of other activation markers, in vivo proliferation and apoptosis coincided after Listeria infection. T cells that had proliferated were over-represented in the apoptotic population. | lld:pubmed |
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| pubmed-article:11972636 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11972636 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11972636 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11972636 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11972636 | pubmed:month | May | lld:pubmed |
| pubmed-article:11972636 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:11972636 | pubmed:author | pubmed-author:ManneringStua... | lld:pubmed |
| pubmed-article:11972636 | pubmed:author | pubmed-author:CheersChristi... | lld:pubmed |
| pubmed-article:11972636 | pubmed:author | pubmed-author:ZhongJieJ | lld:pubmed |
| pubmed-article:11972636 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11972636 | pubmed:volume | 106 | lld:pubmed |
| pubmed-article:11972636 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11972636 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11972636 | pubmed:pagination | 87-95 | lld:pubmed |
| pubmed-article:11972636 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:11972636 | pubmed:meshHeading | pubmed-meshheading:11972636... | lld:pubmed |
| pubmed-article:11972636 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11972636 | pubmed:articleTitle | T-cell activation, proliferation and apoptosis in primary Listeria monocytogenes infection. | lld:pubmed |
| pubmed-article:11972636 | pubmed:affiliation | Department of Microbiology and Immunology, University of Melbourne, Victoria Australia. | lld:pubmed |
| pubmed-article:11972636 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11972636 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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