| pubmed-article:11967569 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11967569 | lifeskim:mentions | umls-concept:C0521451 | lld:lifeskim |
| pubmed-article:11967569 | lifeskim:mentions | umls-concept:C2717971 | lld:lifeskim |
| pubmed-article:11967569 | lifeskim:mentions | umls-concept:C0233820 | lld:lifeskim |
| pubmed-article:11967569 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:11967569 | lifeskim:mentions | umls-concept:C1825553 | lld:lifeskim |
| pubmed-article:11967569 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:11967569 | lifeskim:mentions | umls-concept:C1014081 | lld:lifeskim |
| pubmed-article:11967569 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:11967569 | pubmed:dateCreated | 2002-5-28 | lld:pubmed |
| pubmed-article:11967569 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11967569 | pubmed:abstractText | HtrA2/Omi, a mitochondrial serine protease in mammals, is important in programmed cell death. However, the underlining mechanism of HtrA2/Omi-mediated apoptosis remains unclear. Analogous to the bacterial homolog HtrA (DegP), the mature HtrA2 protein contains a central serine protease domain and a C-terminal PDZ domain. The 2.0 A crystal structure of HtrA2/Omi reveals the formation of a pyramid-shaped homotrimer mediated exclusively by the serine protease domains. The peptide-binding pocket of the PDZ domain is buried in the intimate interface between the PDZ and the protease domains. Mutational analysis reveals that the monomeric HtrA2/Omi mutants are unable to induce cell death and are deficient in protease activity. The PDZ domain modulates HtrA2/Omi-mediated cell death activity by regulating its serine protease activity. These structural and biochemical observations provide an important framework for deciphering the mechanisms of HtrA2/Omi-mediated apoptosis. | lld:pubmed |
| pubmed-article:11967569 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11967569 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11967569 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11967569 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11967569 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11967569 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:11967569 | pubmed:issn | 1072-8368 | lld:pubmed |
| pubmed-article:11967569 | pubmed:author | pubmed-author:SrinivasulaSr... | lld:pubmed |
| pubmed-article:11967569 | pubmed:author | pubmed-author:ZhangZhiJiaZ | lld:pubmed |
| pubmed-article:11967569 | pubmed:author | pubmed-author:AlnemriEmad... | lld:pubmed |
| pubmed-article:11967569 | pubmed:author | pubmed-author:ShiYigongY | lld:pubmed |
| pubmed-article:11967569 | pubmed:author | pubmed-author:LiPingweiP | lld:pubmed |
| pubmed-article:11967569 | pubmed:author | pubmed-author:ChaiJijieJ | lld:pubmed |
| pubmed-article:11967569 | pubmed:author | pubmed-author:LiWenyuW | lld:pubmed |
| pubmed-article:11967569 | pubmed:author | pubmed-author:WuJia-WeiJW | lld:pubmed |
| pubmed-article:11967569 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11967569 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:11967569 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11967569 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11967569 | pubmed:pagination | 436-41 | lld:pubmed |
| pubmed-article:11967569 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11967569 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11967569 | pubmed:articleTitle | Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi. | lld:pubmed |
| pubmed-article:11967569 | pubmed:affiliation | Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey 08544, USA. | lld:pubmed |
| pubmed-article:11967569 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11967569 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11967569 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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