| pubmed-article:11953851 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11953851 | lifeskim:mentions | umls-concept:C0009450 | lld:lifeskim |
| pubmed-article:11953851 | lifeskim:mentions | umls-concept:C0231335 | lld:lifeskim |
| pubmed-article:11953851 | lifeskim:mentions | umls-concept:C0006118 | lld:lifeskim |
| pubmed-article:11953851 | lifeskim:mentions | umls-concept:C1314792 | lld:lifeskim |
| pubmed-article:11953851 | lifeskim:mentions | umls-concept:C1550587 | lld:lifeskim |
| pubmed-article:11953851 | lifeskim:mentions | umls-concept:C0683922 | lld:lifeskim |
| pubmed-article:11953851 | lifeskim:mentions | umls-concept:C0037745 | lld:lifeskim |
| pubmed-article:11953851 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:11953851 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:11953851 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:11953851 | pubmed:dateCreated | 2002-4-15 | lld:pubmed |
| pubmed-article:11953851 | pubmed:abstractText | To investigate whether infections or other environmental exposures may be involved in the aetiology of childhood central nervous system tumours, we have analysed for space-time clustering and seasonality using population-based data from the North West of England for the period 1954 to 1998. Knox tests for space-time interactions between cases were applied with fixed thresholds of close in space, <5 km, and close in time, <1 year apart. Addresses at birth and diagnosis were used. Tests were repeated replacing geographical distance with distance to the Nth nearest neighbour. N was chosen such that the mean distance was 5 km. Data were also examined by a second order procedure based on K-functions. Tests for heterogeneity and Edwards' test for sinusoidal variation were applied to examine changes of incidence with month of birth or diagnosis. There was strong evidence of space-time clustering, particularly involving cases of astrocytoma and ependymoma. Analyses of seasonal variation showed excesses of cases born in the late Autumn or Winter. Results are consistent with a role for infections in a proportion of cases from these diagnostic groups. Further studies are needed to identify putative infectious agents. | lld:pubmed |
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| pubmed-article:11953851 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11953851 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11953851 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11953851 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11953851 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11953851 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:11953851 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:11953851 | pubmed:author | pubmed-author:TaylorG MGM | lld:pubmed |
| pubmed-article:11953851 | pubmed:author | pubmed-author:EganL JLJ | lld:pubmed |
| pubmed-article:11953851 | pubmed:author | pubmed-author:BirchJ MJM | lld:pubmed |
| pubmed-article:11953851 | pubmed:author | pubmed-author:AlexanderF... | lld:pubmed |
| pubmed-article:11953851 | pubmed:author | pubmed-author:KelseyA MAM | lld:pubmed |
| pubmed-article:11953851 | pubmed:author | pubmed-author:CairnsD PDP | lld:pubmed |
| pubmed-article:11953851 | pubmed:author | pubmed-author:McNallyR J... | lld:pubmed |
| pubmed-article:11953851 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11953851 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:11953851 | pubmed:volume | 86 | lld:pubmed |
| pubmed-article:11953851 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11953851 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11953851 | pubmed:pagination | 1070-7 | lld:pubmed |
| pubmed-article:11953851 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:11953851 | pubmed:meshHeading | pubmed-meshheading:11953851... | lld:pubmed |
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| pubmed-article:11953851 | pubmed:meshHeading | pubmed-meshheading:11953851... | lld:pubmed |
| pubmed-article:11953851 | pubmed:meshHeading | pubmed-meshheading:11953851... | lld:pubmed |
| pubmed-article:11953851 | pubmed:meshHeading | pubmed-meshheading:11953851... | lld:pubmed |
| pubmed-article:11953851 | pubmed:meshHeading | pubmed-meshheading:11953851... | lld:pubmed |
| pubmed-article:11953851 | pubmed:meshHeading | pubmed-meshheading:11953851... | lld:pubmed |
| pubmed-article:11953851 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11953851 | pubmed:articleTitle | An infectious aetiology for childhood brain tumours? Evidence from space-time clustering and seasonality analyses. | lld:pubmed |
| pubmed-article:11953851 | pubmed:affiliation | Cancer Research UK Paediatric & Familial Cancer Research Group, Central Manchester and Manchester Children's University Hospitals NHS Trust, Manchester M27 4HA, UK. richard.mcnally@man.ac.uk | lld:pubmed |
| pubmed-article:11953851 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11953851 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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